Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Long-term consumption of Western diet contributes to endothelial dysfunction and aortic remodeling in rats: Implication of Rho-kinase signaling
Faculty
Pharmacy
Year:
2018
Type of Publication:
ZU Hosted
Pages:
Authors:
Rania Ali Mohamed Ali Elrashedy
Staff Zu Site
Abstract In Staff Site
Journal:
Clinical and Experimental Hypertension Taylor&francis
Volume:
Keywords :
Long-term consumption , Western diet contributes , endothelial
Abstract:
Western diet (WD), rich in saturated fat and sugars, has become a risk factor for obesity and metabolic syndrome, however, its effect on endothelial function and vascular remodeling is not fully elucidated. Recent evidence suggests cross-talk between Rho kinase (ROCK) pathway and cardiovascular system. We aimed to investigate the effect of WD on aortic remodeling and the contribution of ROCK signaling. Eight week old male Sprague-Dawley rats were fed either standard chow diet (SD) or high fructose/high-fat diet, typically as in WD. After 42 weeks, WD-fed rats showed hyperglycemia, dyslipidemia, and hypertension without marked weight gain, compared to SD-fed rats. Significant up-regulation of ROCK-1 and -2, along with a decline in eNOS expression were found in the aortic tissue of WD-fed rats. Additionally, WD-fed rats displayed oxidative stress and fibrosis in their aortic tissues versus controls. Our findings suggest that long-term feeding of WD contributes to endothelial dysfunction and aortic remodeling in adult male rats. ROCK activation seems to be involved in WD-related vascular disorders and may represent a promising therapeutic target.
Author Related Publications
Rania Ali Mohamed Ali Elrashedy, "Cilostazol preconditioning alleviates cyclophosphamide-induced cardiotoxicity in male rats: Mechanistic insights into SIRT1 signaling pathway", Elsevier, 2020
More
Rania Ali Mohamed Ali Elrashedy, "Pioglitazone attenuates cardiac fibrosis and hypertrophy in a rat model of diabetic nephropathy", SAGE, 2012
More
Rania Ali Mohamed Ali Elrashedy, "Beneficial effects of pioglitazone against cardiovascular injury are enhanced by combination with aliskiren in a rat model of diabetic nephropathy", Willy, 2012
More
Rania Ali Mohamed Ali Elrashedy, "Bladder function in mice with inducible smooth muscle-specific deletion of the manganese superoxide dismutase gene", APS, 2015
More
Rania Ali Mohamed Ali Elrashedy, "Functional and morphological alterations of the urinary bladder in type 2 diabetic FVBdb/db mice", Elsevier Inc, 2016
More
Department Related Publications
Rawya Sarhan Amien Sarhan, "Feed Intake, Reproductive Performance, Digestibility And Blood Metabolites In Adult NZW Rabbits Fed Diets Containing RAW OR Autoclaved Jackbean Seeds (Canavalia Ensiformis,L.). ", لايوجد, 1900
More
Rawya Sarhan Amien Sarhan, "Effects of Norfloxacin (Noroxin) and Ofloxacin (Tarivid) on Liver and Kidney Functions and Some Other Parameters of Adult Male Rats", لايوجد, 1900
More
Mervat Alsayed Ibrahiem Elsayed Askar, "Serum CRP in STZ-diabetic rats and its correlation with cytokines: evidence for chronic inflammation and a trial for treatment", لايوجد, 1900
More
Hoda Alsayed Mohammid, "Effect of vitamin a enriched diet on lipid metabolism in Rats.", لايوجد, 1900
More
Hoda Alsayed Mohammid, "Comparative study of hepato-renal toxicity of some cephalosporin in rats", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف