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The predictive value of vanin-1 in pediatric immune thrombocytopenia
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Amal Ahmed Ali Zedan
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Hospital Medicine Ain Shams University Faculty of Medicine
Volume:
Keywords :
, predictive value , vanin-1 , pediatric immune thrombocytopenia
Abstract:
Background: Immune thrombocytopenia (ITP) has oxidative stress-related pathway as one of its possible mechanisms. Vanin-1 (VNN1) is an oxidative stress sensitive sensor. Objective: The present study was conducted to assess the clinical significance of VNN1 in pediatric ITP patients. Patients and Methods: A total of 50 kids with ITP have been involved in this work; 25 newly diagnosed, 25 chronic patients with ITP more than 12 months (15 responders and 10 non responders to treatment) and 25 apparently healthy children. All groups had their serum VNN-1 levels checked using a two-antibody sandwich enzyme-linked immunosorbent test. Results: The serum VNN1 level was significantly higher in ITP group than control group (p˂0.001). The level of serum VNN1 was significantly very high in newly diagnosed ITP group (p˂0.001) in comparison to chronic responders and chronic non responders ITP groups. Moreover, there was a significant increase in serum VNN1 level in chronic non responders ITP group (p˂0.001) compared to chronic responders group. In newly diagnosed ITP group, both age (r=-0.62, p=0.006) and the platelet count (r=-0.46, p=0.01) had a significant negative connection with serum VNN1 level. A cut-off value lower than 0.6 ng/ml for serum VNN1 could be used to distinguish the chronic non-responders ITP from chronic responders patients with 100 percent specificity and 90 percent sensitivity. Conclusion: From our current results, it is hypothesized that high VNN1 level plays a role in the pathogenesis and progress of pediatric ITP
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Amal Ahmed Ali Zedan, "The role of interleukin-22 in pityriasis rosea", British Association of Dermatologists, 2017
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Amal Ahmed Ali Zedan, "Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients", Brazilian Society of Nephrology, 2016
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Amal Ahmed Ali Zedan, "Topical use of autologous platelet rich plasma in myringoplasty", Amsterdam : Elsevier Science, 2015
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Department Related Publications
Amina Mohamed Talaat Mahmoud Elnagar, "7-Assessment of TNF-Related Apoptosis Inducing Ligand (TRAIL) Expression and Liver Damage in Chronic Hepatitis B Infection", لايوجد, 1900
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Enas Alsayed Ahmed Soelam, "1- Significance of thyroid peroxidase and thyroglobulin antibodies and same parameters of cell mediated immunity in cases of post partum thyroid dysfunction.", لايوجد, 1900
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Enas Alsayed Ahmed Soelam, "6- Siooprotein related to hypoxia ischemic encephalopathy (HIE) in neuborn infants.", لايوجد, 1900
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