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Serum levels of leptin and adiponectin in patients with multiple sclerosis
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Amal Ahmed Ali Zedan
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Neurology, Psychiatry and Neurosurgery Springer Nature
Volume:
Keywords :
Serum levels , leptin , adiponectin , patients with
Abstract:
Background: The role of adipokines such as leptin and adiponectin in regulating the immunity has been documented, however data concerning their consequence on multiple sclerosis (MS) Egyptian patients are deficient. The aim of this study is to demonstrate the serum levels of leptin and adiponectin in MS patients and to assess their association with disease disability and severity. A case–control study including 60 subjects (30 MS patients and 30 age, sex and body mass index-matched healthy controls) was performed. Results: Serum leptin level was significantly higher among MS patients than controls (P < 0.001) while adiponectin was not significantly elevated in MS patients (P = 0.24). There was a significant positive correlation between leptin levels with MS disability (Expanded Disability Status Scale) (r = 0.678; P < 0.001), severity (Multiple Sclerosis Severity Score) (r = 0.631; P < 0.001) and progression (progression index) (r = 0.461; P = 0.01). There was no statistically significant correlation between adiponectin with disease disability, severity or progression. Conclusions: MS patients had significantly higher serum leptin levels and insignificant adiponectin levels compared to controls. Leptin has a potential role in multiple sclerosis disability and severity. However, adiponectin is not useful as a biomarker of MS disease, disability and severity
Author Related Publications
Amal Ahmed Ali Zedan, "NT-proBNP as early marker of subclinical late cardiotoxicity after doxorubicin therapy and mediastinal irradiation in childhood cancer survivors", New York, NY : Hindawi Pub. Corp, 2015
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Amal Ahmed Ali Zedan, "Prevalence of hepatitis C infection among diabetics type 2 at Sharkia Governorate, Egypt", Zagazig University, 2015
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Amal Ahmed Ali Zedan, "The role of interleukin-22 in pityriasis rosea", British Association of Dermatologists, 2017
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Amal Ahmed Ali Zedan, "Serum uric acid and its association with hypertension, early nephropathy and chronic kidney disease in type 2 diabetic patients", Brazilian Society of Nephrology, 2016
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Amal Ahmed Ali Zedan, "Topical use of autologous platelet rich plasma in myringoplasty", Amsterdam : Elsevier Science, 2015
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Department Related Publications
Amany Mohamed Algohary, " دراسة النيتريت فى البول وبعض مضادات الاكسدة فى الاطفال المصابين بالمتلازمة النفروزية ذات التغير البسيط", لايوجد, 1900
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Enas Alsayed Ahmed Soelam, "3- The significance of serum neopterin, serum malondialdehyde and urinary nitrite in children with idiopathic nephrotic syndrome. ", لايوجد, 1900
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Enas Alsayed Ahmed Soelam, "12- Glutathione S- transferase polymorphisms (GSTT1) in children with acute Myeloid leukemia.", لايوجد, 1900
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Enas Alsayed Ahmed Soelam, "15- Endocrimal alteration in Neonatal sepsis. ", لايوجد, 1900
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Hossameldeen Salah Mohamed Abdelhaliem, "1- First time febrile seizure associated infection: A study of the three common viruses versus bacterial infection.", لايوجد, 1900
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