Compliance of Blood Relatives of Colorectal Cancer Patients to Colorectal Screening Guidelines Background: There is a wide range of options for colorectal cancer (CRC) screening in the average-risk population. However, screening tests for CRC vary regarding the degree of supporting evidence. Colonoscopy, Satisfaction, and Safety Questionnaire based on patients’ experience (CSSQP). Aim of the Study To study the compliance of blood relatives of patients with colorectal cancer to colorectal cancer screening. Subject and Methods This cross-sectional study included 134 participants of blood relatives of CRC patients undergoing colonoscopy following primary care or secondary care referrals, after exclusion of those who refused to take part, and subjects already having or had cancer elsewhere. This work was conducted in Internal Medicine Department, Zagazig University Hospitals. All participants in this study completed a questionnaire, which comprised a pre-procedure questionnaire that included name, age, residence, history of smoking, history of bleeding problems, history of colonoscopy, and family history of colon cancer. Results The age of the studied cases ranged from 19 to 66 years with a mean of 44.08 years. Regarding the sex distribution, 53% were male. Most of the study group were married (84.3%). More than half of the studied group were educated (57.2%). The most frequent occupations were professional (29.1%). Of the studied cases, 60.4% had enough income and 47.8% were smokers. The study group had no history of other malignancy or previous colonoscopy. All the studied cases refused colonoscopy for screening, but 91% of them accepted CRC genetic tests and all of them accepted any other tests like stool analysis or CT scan. Regarding advising others to do a colonoscopy, 66.4% advised cases with symptoms to do a colonoscopy. Finally, 82.8% of the studied group preferred medical treatment if they had symptoms. There was a statistically significant increase in the frequency of acceptance of CRC genetic tests among educated compared to non-educated and among those who had enough income compared to those who did not have enough income. Conclusion Providing non-invasive screening choices can augment participation in programs for colorectal cancer screening. The success of a screening program depends on having tests with acceptable performance, but also on the willingness of the target population to take part. This study showed that offering non-invasive tests, options significantly increase compliance to colorectal cancer screening.