Impact of Hepatitis C Viral Load in Chronic Kidney Disease Patients Background and study aims: Chronic hepatitis C virus (HCV) infection is linked to chronic kidney disease (CKD) and hastens its progress to end-stage renal disease (ESRD). Previous studies have examined the association between chronic HCV and CKD and reported that HCV is correlated with proteinuria but not with low estimated glomerular filtration rate (eGFR) depending mainly on anti-HCV antibodies to diagnose chronic HCV infection. However, it is the HCV viral load to diagnose active HCV infection. Therefore, our study aimed to elucidate the relationship between HCV viral load and CKD Patients/Material and Method: It’s a cross-sectional observational study that included 204 subjects that were classified into group 1 (90 chronic HCV patients without a history of chronic kidney disease) and group 2 (114 chronic HCV patients with a history of chronic kidney disease). All subjects underwent full history taking, medical examination, and laboratory investigation from May 2017 to May 2019 Results: In CKD patients, HCV viral load was correlated with age, platelet count serum creatinine, eGFR, and serum bilirubin. Higher HCV viral load was one of the significant predictors of low eGFR in patients with chronic HCV infection in addition to the female sex, older age lower hemoglobin, higher international normalized ratio, and higher alanine transaminase Conclusion: There is a strong positive association between HCV viral load and serum creatinine in CKD patients. Higher HCV viral load carries a greater risk for lower eGFR in patients with chronic HCV infection