Epidermal growth factor is an endocrine product of the submandibular gland, the liver is an important target of its action and is affected by sialoadenectomy. Thirty rats were used in this study and divided into group I (sham operated animals), group II (sialoadenectomy after 4 weeks) and group III (sialoadenectomy after 10 weeks). Liver samples were processed for light and electron microscope examination. Sialoadenectomy induced mild to moderate liver damage which persists up to ten weeks after the operation. This damage is manifested morphologically rather than functionally, affecting the general structure, hepatocytes, hepatic stellate cells and hepatic sinusoids. Key words: sialoadenectomy; liver; rat; hepatic stellate cells.