Background: Acrylamide is toxic both in experimental animals and in humans. It is proved to be carcinogenic in rodents and considered by The International Agency for Research on Cancer as a probable human carcinogen. Medicinal plants have significant antioxidant properties. Ginger had the highest antioxidant activity among these plants. Aim of the work: To detect the histopathological effects of acrylamide on the kidneys in postnatal rats and to determine the possible protective effect of Ginger (Zingiber officinale Roscoe) as an antioxidant. Methods: The experimental pregnant rats were randomly divided into 3 groups: Group 1 (control group): these rats were preserved under normal condition of diet and water. Group 2 (acrylamide-treated group): acrylamide was orally administered to non-anesthetized rats by gastric intubation at a dose of 10 mg/kg/day. Group 3 (ginger-protected group): animals of this group were given the same dose of acrylamide as in group 2 followed by 1 ml of final aqueous extract of ginger (24 mg/ml) three times weekly. All the doses were administered from the 7th day of gestation and continued up to 21 days after delivery. Postnatal rats at the 2nd and 21st days were selected from each group and were scarified. Their kidneys were carefully dissected, removed and fixed in 10% formalin for histopathological and immunohistochemical examinations. Results: Maternal acrylamide administration disturbed the development of the renal cortex of the offsprings. Histological examination of acrylamide-treated, 2-day-old rats revealed degenerated glomeruli with lack of capillary tufts, disarrangement of podocytes and thickening of the parietal layers of Bowman's capsules. Moreover, the damage was evident in the primitive tubules. Examination of acrylamide-treated, 21-day-old rats showed congested glomerular capillaries, mesangial hypercellularity, vacuolations and darkly stained nuclei of the renal tubular epithelium, and extensive interstitial cellular infiltration and hemorrhage. Statistically, acrylamide–treated groups at both ages showed a highly significant decrease in the mean glomerular count, and the mean thickness of the cortex and the medulla as compared to their control groups. Moreover, the area percentage of renal NF-kβ protein expression showed a significant increase with acrylamide treatment. Ginger administration effectively restored most of the acrylamide-induced renal cortical damage.