The researcher "Lamyaa Ahmed Taha Hassan" a study aims to identify (The Effect Of Cardio Training On Some Physiological Variables and Skill Performance In Handball), The researcher used a semi-experimental design for one group with a pre-post measurement, The sample included (12) players who are players of the handball team zagzig universty for 2019/2020 academic year,This program have continue for (8) weeks by (3) units per-week, The results of this study indicated that the proposed program using cardio exercises led to an improvement in the physiological variables under investigation, and also led to an increase in the level of offensive skill performances for the players, The researcher recommended the necessity of guiding the cardio exercises when training handball players, Which actively contribute to improving and developing physiological and skill variables.