Nile tilapia (Oreochormis niloticus) is considered one of the top cultured fish in Egypt and the second globally. The high demand for animal protein was associated with intensive fish culturing, which resulted in the emergence of disease outbreaks causing significant losses in tilapia aquaculture among the recent years. With special reference to bacterial outbreaks, Aeromonas veronii (A. veronii) is a recently reported bacterial pathogen affecting farmed tilapia and other fish species worldwide. A. veronii has been notified as a significant threat on Nile tilapia populations resulting in heavy mortality and was recorded to have a wide range of antibiotic resistance. Subsequently, recent publications focused on immunostimulant alternatives. The previous science data on summer tilapia mortality phenomena were outlined in this review article with special reference to A. veronii as an important pathogen. Clinical and postmortem symptoms, histopathological lesions, genetic diversity, and associations with others submitted to GenBank, diagnosis, control steps, and significance to public health were highlighted.