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Role of interferon gamma in SARS CoV 2 positive patients with parasitic infections
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Dina Sameh Mohamed Elrafey
Journal:
Gut pathogens BMC part of springer nature
Volume:
Keywords :
Role , interferon gamma , SARS , , positive patients
Abstract:
Background: By 27 June 2020, almost half a million people had died due to COVID-19 infections. The susceptibility and severity of infection vary significantly across nations. The contribution of chronic viral and parasitic infections to immune homeostasis remains a concern. By investigating the role of interferon (IFN)-γ, we conducted this study to understand the connection between the decrease in numbers and severity of COVID-19 cases within parasitic endemic regions. Methods: Our research included 375 patients referred to hospitals for diagnosis of COVID-19 infection. Patients were subjected to full investigations, in particular severe acute respiratory syndrome coronavirus-2 nucleic acid and Toxoplasma IgM and IgG antibody detection, stool examination, and quantitative IFN-γ measurement. Results: The majority of the studied cases had chest manifestation either alone (54.7%) or in association with gastrointestinal (GIT) manifestations (19.7%), whereas 25.6% had GIT symptoms. We reported parasitic infections in 72.8% of mild COVID-19 cases and 20.7% of severe cases. Toxoplasma gondii, Cryptosporidium, Blastocyst, and Giardia were the most common parasitic infections among the COVID-19 cases studied. Conclusion: The remarkable adaptation of human immune response to COVID- 19 infection by parasitic infections with high levels of IFN-γ was observed in moderate cases compared with low levels in extreme cases. The potential therapeutic efforts aimed at the role of parasitic infection in immune system modulation are needed if this hypothesis is confirmed.
Author Related Publications
Dina Sameh Mohamed Elrafey, "Effect of rotating shift work on the level of some hormones and quality of life of resident physicians in Zagazig university hospital", Egyprtian journal of occupational medicine, 2016
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Dina Sameh Mohamed Elrafey, "Ethyl Glucuronide, Ethyl Sulfate and Acetone as Biomarkers for Alcohol Based Hand Sanitizers Chronic Exposure in Health Care Workers", Ain Shams University, Faculty of Medicine, Forensic Medicine & Clinical Toxicology Department, 2019
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Dina Sameh Mohamed Elrafey, "Impact of biologics drugs adherence on treatment outcomes and work productivity of Al Sharqia Governorate patients with Ankylosing Spondylitis", Zagazig university, faculty of medicine, 2021
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Dina Sameh Mohamed Elrafey, "Telepsychiatry versus face to face consultation in COVID-19 Era from the patients’ perspective", EL Sevier, 2021
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Dina Sameh Mohamed Elrafey, "COVID-19 Infection Stigma Scale: psychometric properties", Egyptian Society of Neurology, Psychiatry and Neurosurgery (ESNPN), 2021
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Department Related Publications
Gamal Alsayed Breek Mohamed, "تأثير مستوى الرصاص فى دم الأمهات على القياسات الأنثروبومترية و مقاييس الدم لدى مواليدهم", لايوجد, 1900
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Gamal Alsayed Breek Mohamed, "دراسة وراثية على العاملين فى تصنيع الأثاث الخشبية", لايوجد, 1900
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Hosneya Mohamed Ragab, "التعرض لعنصر الزئبق لدى ممارس طب الاسنان : دراسة وبائية ", لايوجد, 1900
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Hosneya Mohamed Ragab, "تقييم الاستفادة من خدمات الرعاية الصحية الاساسية فى المناطق الريفية فى محافظة الشرقية ", لايوجد, 1900
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Hosneya Mohamed Ragab, "الأطفال المصابون بالأمراض المزمنة الصفات الديمجرافيه والاجتماعية والنفسية للأسرة ", لايوجد, 1900
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