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Histological and Immunohistochemical Study on the Effect of Prenatal Administration of Diclofenac Sodium on Maternal and Neonatal Organs in albino rat
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Hanan Alsayed Lotfy Mokhtar
Staff Zu Site
Abstract In Staff Site
Journal:
Zagazig University Medical Journal Zagazig University Medical Journal
Volume:
Keywords :
Histological , Immunohistochemical Study , , Effect , Prenatal Administration
Abstract:
Background: Diclofenac sodium (DS) can induce developmental abnormalities in embryos if consumed during pregnancy. Objective: To assess the effect of prenatal administration of therapeutic dose of DS during the critical period of organogenesis on development of different neonatal organs of albino rats and on maternal organs, as well as to spotlight on the immunohistochemical reactions that may explain the possible impacts of DS. Material and Methods: After mating, 18 pregnant rats were allocated into three groups. Group (I): received balanced diet, Group (II): received intraperitoneal injection (IP) of 1mL/kg/day of distilled water, Group (III): received IP of 1.5mg/Kg.bw/day of DS dissolved in distilled water from 7th -14th days of gestation. The mothers (6/group) and their newborns (10/group) were anaesthetized following labor. The placentae and livers from mothers and hearts, livers, and lungs from their neonates were examined after preparation using light microscopy, immunohistochemical, morphometric studies and statistical analysis. Results: Histologically, in all DS-treated groups, there was degenerative histopathological changes in the organs of both pregnant albino rats and their neonates. Morphometric and statistical analysis showed highly significant increase in the area percentages of positive TNF-α and iNOS immunoreactions in all DS-treated groups as compared to their control groups. Moreover, the most affected organ in mothers was the placenta while, the lung tissues in neonates. Conclusion: The current investigation found that giving therapeutic doses of DS during the period of organogenesis caused significant histopathological alterations in both maternal and neonatal organs enhanced by upregulation of proinflammatory markers linked to oxidative stress.
Author Related Publications
Hanan Alsayed Lotfy Mokhtar, "Histological and Immunohistochemical Study on The Effect of Prenatal Administration of Diclofenac Sodium on Maternal and Neonatal Organs in albino rat دراسة نسيجية وهيستوكيميائية مناعية عن تأثير إعطاء ديكلوفيناك الصوديوم قبل الولادة على أعضاء الأم وصغارها حديثي الولادة في الجرذ الأبيض", Zagazig University Medical Journal, 2021
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Hanan Alsayed Lotfy Mokhtar, "EFFECT OF FECAL DIVERSION ON HUMAN PEDIATRIC COLONIC MUCOSA: ULTRASTRUCTURE STUDY.", مجلة جامعة الزقازيق الطبية, 2006
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Hanan Alsayed Lotfy Mokhtar, "ANATOMICAL TOPOGRAPHY AND MORPHOMETRY OF THE ASTERION IN ADULT HUMAN EGYPTIAN DRIED SKULLS AND CADAVER", مجلة جامعة الزقازيق الطبية, 2005
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Hanan Alsayed Lotfy Mokhtar, "MEASUREMENTS UTILIZING THE PTERION WITH SPECIAL REFERENCE TO ITS SUTURAL PATTERNS IN ADULT HUMAN EGYPTIAN DRIED SKULLS", بمجلة جامعة الزقازيق الطبية, 2007
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Hanan Alsayed Lotfy Mokhtar, "ULTRASONOGRAFIC ASSESSMENT OF THE NORMAL LIVER AND RIGHT KIDNEY MEASUREMENTS IN SHARKIA: A CORRELATIVE STUDY WITH FETAL PARAM ETERS IN THE PRENATAL STAGE", مجلة جامعة الزقازيق الطبية, 2006
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