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Detection Of Plasmid Mediated Quinolone Resistance Among Isolates From Cirrhotic Patients With Spontaneous Bacterial Peritonitis In A University Hospital
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
2068-2081
Authors:
Maysa Abdullah Saeed Muhmd
Staff Zu Site
Abstract In Staff Site
Journal:
European Journal of Molecular & Clinical Medicine EJMCM
Volume:
6
Keywords :
Detection , Plasmid Mediated Quinolone Resistance Among
Abstract:
Introduction:Spontaneous bacterial peritonitis in advanced liver cirrhosis and its treatment have a global burden in healthcare management especially in our locality. Fluoroquinolones are widely used as prophylaxis in that group of patients. Data concerning the prevalence of PMQR determinants in SBP are quite limited. Purpose: To study prevalence of PMQR determinants in isolates from ascetic fluid of cirrhoticpatients with SBP and the relation to ESBL production. Patients and Methods:Ascetic fluid culture was performed; Identification and antimicrobial susceptibility of isolates weredone by conventional methods. FQ resistant isolate are subjected to double disc synergy test for phenotypic detection of ESBL and Polymerase chain reaction for detection of PMQR determinants. Results:Among total of145 Ecoli, 21 Klebsiella pneumonia and 31 gram positive cocci,we found that 70 Ecoli (48.2%), 10 K pneumonia (47.6%) and 10 (32.2%) Gram positive isolates were FQresistant. All tested FQ-Resistant Gram negative isolates (100%) harbored at least one of studied PMQR genes.acc6`-Ib-cr is most frequent (87.5%) followed by qnrS(81.2%), while qnrB frequency was 12.5% and qepAwas detected in 10% of gram negative bacilli. In Gram positive cocci 6 isolates showed PMQR (acc6`-Ib-cr&qnrSonly). A statistically significant association was found between ESBL producers and acc6`-Ib-cr gene, an association was also found with qnrS gene. Conclusion:PMQR determinants and ESBLs prevalence is high among FQ-resistant isolates from acetic fluid of cirrhotic patients diagnosed with spontaneous bacterial peritonitis. The PMQR genes and their association with ESBL-producing plasmids have a great effect on multidrug resistance spread, thusmight lead to serious problems. Judicious use of quinolones as prophylaxis in SBP patients is essential.
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Maysa Abdullah Saeed Muhmd, "Impact of body mass index on hepatocellular carcinoma recurrence after liver transplantation through long-term follow-up", AME publishing company, 2021
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Maysa Abdullah Saeed Muhmd, "Value of Macrophage Inflammatory Protein 1 Beta and Platelet Indices in Diagnosis of Spontaneous Bacterial Peritonitis", Zagazig University, 2021
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Department Related Publications
Ahmed Mohamed Mahmoud ebrahym, "مدى انتشار الأجسام المناعية لفيرس نقص المناعه فى الانسان والمستضد السطحى لفيرو الإلتهاتب الكبدى ب ، والجسام المناعية لفيروس الإلتهاب الكبدى ج بين المتبرعين بالدم بحافظة الشرقيه :", لايوجد, 1900
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Ahmed Mohamed Mahmoud ebrahym, " التشخيص المناعى للإصابة بطفيل الجارديا عن طريق اكتشاف مستضدات الجيارديا . ", لايوجد, 1900
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Ahmed Mohamed Mahmoud ebrahym, "دراسة بكتيرية باثولوجية للعمدة فى حالات تضخم الكبد والطحال المتوطن ", لايوجد, 1900
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Ahmed Mohamed Mahmoud ebrahym, "الكبد والطحال دراسة بكتيرية باثولوجية للمعدة فى حالات تضخم المتوطن", لايوجد, 1900
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Ahmed Mohamed Mahmoud ebrahym, "مصاحبه فيروس الالتهاب الكبدى ( ج ) وتضخم الكبد والطحال المتوطن", لايوجد, 1900
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