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SATB-1 and Her2 as predictive molecular and immunohistochemical markers for urothelial cell carcinoma of the bladder
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Samia Hussein Aly Mohammed
Staff Zu Site
Abstract In Staff Site
Journal:
Cancer Biomarkers IOS Press
Volume:
Keywords :
SATB-1 , Her2 , predictive molecular , immunohistochemical markers
Abstract:
Studying bladder cancer molecular biology revealed the presence of genetic alterations. So, detection of molecular biomarkers that help in monitoring the disease, evaluating the prognosis of the patients, and their response to therapy is needed. In this study, we investigated the expression and the prognostic significance of SATB-1 and ERBB2 mRNA and protein by quantitative RT-PCR and immunohistochemical analysis in urothelial bladder cancer cases and the surrounding normal bladder tissue. The correlations between the expression of both markers and the clinicopathological parameters were performed with further analysis of the correlation between the expression of SATB-1 and ERBB2. Compared to control, the expression of SATB-1 and ERBB2 mRNA and protein in cancer tissues were significantly up-regulated (p< 0.05). Also, a positive correlation between both markers was found (r= 0.53, p< 0.001). Moreover, elevated levels of both markers were significantly associated with the stage, lymph node involvement at both mRNA and protein levels (p< 0.001). In conclusion, there is a clinical significance of SATB-1 and ERBB2 as potential biomarkers for predicting bladder cancer patients of aggressive behavior and poor prognosis.
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Samia Hussein Aly Mohammed, "Factors Enhancing the Migration and the Homing of Mesenchymal Stem Cells in Experimentally Induced Cardiotoxicity in Rats", Wiley Online Library, 2017
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Samia Hussein Aly Mohammed, "Up-regulated miR-221 expression as a molecular diagnostic marker in laryngeal squamous cell carcinoma and its correlation with Apaf-1 expression", IOS Press, 2017
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Samia Hussein Aly Mohammed, "Functional and Structural Assessment of the Effect of Human Umbilical Cord Blood Mesenchymal Stem Cells in Doxorubicin-Induced Cardiotoxicity", Wiley, 2017
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Department Related Publications
Gamal Alsayed Breek Mohamed, "تأثير مستوى الرصاص فى دم الأمهات على القياسات الأنثروبومترية و مقاييس الدم لدى مواليدهم", لايوجد, 1900
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Gamal Alsayed Breek Mohamed, "دراسة وراثية على العاملين فى تصنيع الأثاث الخشبية", لايوجد, 1900
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Hosneya Mohamed Ragab, "التعرض لعنصر الزئبق لدى ممارس طب الاسنان : دراسة وبائية ", لايوجد, 1900
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Hosneya Mohamed Ragab, "تقييم الاستفادة من خدمات الرعاية الصحية الاساسية فى المناطق الريفية فى محافظة الشرقية ", لايوجد, 1900
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Hosneya Mohamed Ragab, "الأطفال المصابون بالأمراض المزمنة الصفات الديمجرافيه والاجتماعية والنفسية للأسرة ", لايوجد, 1900
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