Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study

Faculty Pharmacy Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Molecules mdpi Volume:
Keywords : Anti-Inflammatory, Antipyretic, , Analgesic Properties , Potamogeton perfoliatus    
Abstract:
Natural antioxidants, especially those of plant origins, have shown a plethora of biological activities with substantial economic value, as they can be extracted from agro-wastes and/or under exploited plant species. The perennial hydrophyte, Potamogeton perfoliatus, has been used traditionally to treat several health disorders; however, little is known about its biological and its medicinal effects. Here, we used an integrated in vitro and in vivo framework to examine the potential effect of P. perfoliatus on oxidative stress, nociception, inflammatory models, and brewer’s yeast-induced pyrexia in mice. Our results suggested a consistent in vitro inhibition of three enzymes, namely 5-lipoxygenase, cyclooxygenases 1 and 2 (COX-1 and COX-2), as well as a potent antioxidant effect. These results were confirmed in vivo where the studied extract attenuated carrageenan-induced paw edema, carrageenan-induced leukocyte migration into the peritoneal cavity by 25, 44 and 64% at 200, 400 and 600 mg/kg, p.o., respectively. Moreover, the extract decreased acetic acid-induced vascular permeability by 45% at 600 mg/kg, p.o., and chemical hyperalgesia in mice by 86% by 400 mg/kg, p.o., in acetic acid-induced writhing assay. The extract (400 mg/kg) showed a longer response latency at the 3 h time point (2.5 fold of the control) similar to the nalbuphine, the standard opioid analgesic. Additionally, pronounced antipyretic effects were observed at 600 mg/kg, comparable to paracetamol. Using LC-MS/MS, we identified 15 secondary metabolites that most likely contributed to the obtained biological activities. Altogether, our findings indicate that P. perfoliatus has anti-inflammatory, antioxidant, analgesic and antipyretic effects, thus supporting its traditional use and promoting its valorization as a potential candidate in treating oxidative stress-associated diseases.
   
     
 
       

Author Related Publications

  • Aseem Mohamed Mohamed Elshazly Hamouda, "HPLC-ESI-MS/MS profiling of polyphenolics of a leaf extract from Alpinia zerumbet (Zingiberaceae) and its anti-inflammatory, anti-nociceptive, and antipyretic activities in vivo.", mdpi, 2018 More
  • Aseem Mohamed Mohamed Elshazly Hamouda, "Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies", mdpi, 2021 More
  • Aseem Mohamed Mohamed Elshazly Hamouda, "Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats", Elsevier, 2021 More
  • Aseem Mohamed Mohamed Elshazly Hamouda, "Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats", Elsevier, 2021 More
  • Aseem Mohamed Mohamed Elshazly Hamouda, "Syzygium aqueum (Burm.f.) Alston Prevents Streptozotocin-Induced Pancreatic Beta Cells Damage via the TLR-4 Signaling Pathway", Frontiers, 2021 More

Department Related Publications

  • Amro Abdelraof Abdelghany Mahmoud, "Antifibrotic activity of hesperidin against dimethylnitrosamineinduced liver fibrosis in rats", Springer, 2014 More
  • Amro Abdelraof Abdelghany Mahmoud, "Hibiscus sabdariffa extract alleviates vascular complications in streptozotocin-induced diabetic rats", Faculty of Pharmacy, Zagazig University, 2016 More
  • Eslam Ahmed Abdelhamid ebrahiem, "GSK-3 heterozygous knockout is cardioprotective in a knockin mouse model of familial dilated cardiomyopathy", Am J Physiol Heart Circ Physiol, 2016 More
  • Mona Fouad Mahmoud Abdelaziz, "Mexican tea (Dysphania ambrosioides (L.) Mosyakin & Clemants) seeds attenuate tourniquet-induced hind limb ischemia–reperfusion injury by modulating ROS and NLRP3 inflammasome pathways", Elsevier, 2023 More
  • Mona Fouad Mahmoud Abdelaziz, "Euphorbia honey: a comprehensive compile of its traditional use, quality parameters, authenticity, adulteration, and therapeutic merits", Springer Netherlands, 2023 More
Tweet