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The role of forskolin as a lipolytic stimulator during in vitro oocyte maturation and the in vitro embryo production of livestock
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
1486– 1496
Authors:
Mayada Ragab Farag Awadallah
Staff Zu Site
Abstract In Staff Site
Journal:
Reproduction in Domestic Animals Wiley
Volume:
Keywords :
, role , forskolin , , lipolytic stimulator during , vitro
Abstract:
Cryopreservation is a modern technique which assists in the preservation of genetic material from oocytes and embryos for a long time. However, elevated vulnerability to cryopreservation due to the large accumulation of intracellular lipids within oocytes or embryos avoids success of this method. These lipids remain the main crucial factor limiting survival rates of oocytes and embryos after thawing. Lipid ingathering in the oocyte cytoplasm augments lipid peroxidation (LPO) and oxidative stress increases the apoptosis process, declines the viability after thawing, declines cytoskeleton actin filament injuries, lowers the blastocyst rates and reduces cryotolerance in the early stages of embryo development. There have been several attempts to reduce the ingathering of intracellular lipids in oocytes or embryos during the cryopreservation process, in that way enhancing the competence of cryopreserved oocytes or embryos and increasing their viability. One of the most applied agents for chemical delipidation is forskolin. Forskolin exhibited a possible part in improving the oocytes cryopreservation through stimulating cyclic adenosine monophosphate (cAMP) production. The main purpose of cAMP modulation is to provide energy to sustain the mammalian oocytes´ meiotic arrest. The purpose of the existing article is to assess and offer more evidence concerning the forskolin utilization as a modulator of cAMP during the cryopreservation of oocytes and its influence on meiosis completion and the reorganization of cytoplasm, which are prerequisites for the development of oocytes in addition to the contribution to fertilization and subsequently, the development of embryos.
Author Related Publications
Mayada Ragab Farag Awadallah, "Ameliorative impact of taurine on oxidative damage induced by Ipomoea carnea toxicity in wistar male rats through modulation of oxidative stress markers, apoptotic and Nrf2 pathway", Elsevier, 2021
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Mayada Ragab Farag Awadallah, "A comprehensive review on the health benefits and nutritional significance of fucoidan polysaccharide derived from brown seaweeds in human, animals and aquatic organisms", Wiley, 2021
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Mayada Ragab Farag Awadallah, "Palliative Effects of Spirulina platensis Against Cadmium Induced Hepaotoxicity in Albinob Rats", Faculty of Veterinary Medicine, 2015
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Mayada Ragab Farag Awadallah, "Differential susceptibility of kidneys and livers to proliferative processes and transcriptional level of the genes encoding desmin, vimentin, connexin 43, and nestin in rats exposed to furan", elseiver, 2018
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Mayada Ragab Farag Awadallah, "Evaluating the ameliorative efficacy of Spirulina platensis on spermatogenesis and steroidogenesis in cadmium-intoxicated rats", springer, 2016
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Department Related Publications
Ali Heder Abdelrahman Abohaded, "Detection and Distribution of the Rodenticide Klerat in Rat Tissue", لايوجد, 1900
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