In Vitro Antitumor Evaluation of Some Hybrid Molecules Containing Coumarin and Quinolinone Moieties

Faculty Science Year: 2019
Type of Publication: ZU Hosted Pages: 2010-2018
Authors:
Mustafa Salahuddin Abdul Hamid Hasan
Journal: Anti-Cancer Agents in Medicinal Chemistry (Formerly Current Medicinal Chemistry-Anti-Cancer Agents Bentham Science Publishers Volume: 19
Keywords : , Vitro Antitumor Evaluation , Some Hybrid Molecules    
Abstract:
Hybrid molecules furnished by merging two or more pharmacophores is an emerging concept in the field of medicinal chemistry and drug discovery. Currently, coumarin hybrids have attracted the keen attention of researchers to discover their therapeutic capability against cancer. Objective: The present study aimed to evaluate the in vitro antitumor activity of a new series of hybrid molecules containing coumarin and quinolinone moieties 4 and 5 against four cancer cell lines. Materials and Methods: A new series of hybrid molecules containing coumarin and quinolinone moieties, 4a-c and 5a-c, were synthesized and screened for their cytotoxicity against prostate PC-3, breast MCF-7, colon HCT- 116 and liver HepG2 cancer cell lines as well as normal breast Hs-371 T. Results: All the synthesized compounds were assessed for their in vitro antiproliferative activity against four cancer cell lines and severa
    
     
 
       

Author Related Publications

  • Mustafa Salahuddin Abdul Hamid Hasan, "In Vivo Biological Evaluation of Ethyl 4-(7-hydroxy-4-methyl-2-oxoquinolin-1-ylamino)-coumarin-3-carboxylate as an Antitumor Agent", Bentham Science Publishers, 2020 More
  • Mustafa Salahuddin Abdul Hamid Hasan, "Synthesis and molecular docking of hybrids ionic azole Schiff bases as novel CDK1 inhibitors and anti-breast cancer agents: In vitro and in vivo study", ScienceDirect, 2021 More
  • Mustafa Salahuddin Abdul Hamid Hasan, "Study of the protective and antioxidant activities of the extract of nelumbo nucifera seed against CCL4-induced damage of liver and kidney in female rats", Folium Publishing Company, 2015 More
  • Mustafa Salahuddin Abdul Hamid Hasan, "GC-MS analysis of phytocomponents in the ethanolic extract of Nelumbo nucifera seeds from Russia", MediPoeia, 2015 More
  • Mustafa Salahuddin Abdul Hamid Hasan, "Hepatoprotective and antioxidant activities of the extract of Nelumbo nucifera leaves against CCl4-induced liver damage in female rats", Astrakhan State University, 2015 More

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