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Thymol Nanoemulsion: A New Therapeutic Option for Extensively Drug Resistant Foodborne Pathogens
Faculty
Veterinary Medicine
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Marwa Ibrahim Ibrahiem Abdelhamied
Staff Zu Site
Abstract In Staff Site
Journal:
Antibiotics MDPI
Volume:
Keywords :
Thymol Nanoemulsion: , , Therapeutic Option for Extensively Drug
Abstract:
Foodborne pathogens have been associated with severe and complicated diseases. Therefore, these types of infections are a concern for public health officials and food and dairy industries. Regarding the wide-spread multidrug resistant (MDR) and extensively drug resistant (XDR) foodborne pathogens such as Salmonella Enteritidis (S. Enteritidis), new and alternative therapeutic approaches are urgently needed. Therefore, we investigated the antimicrobial, anti-virulence, and immunostimulant activities of a stable formulation of thymol as thymol nanoemulsion in an in vivo approach. Notably, treatment with 2.25% thymol nanoemulsion led to a pronounced improvement in the body weight gain and feed conversion ratio in addition to decreases in the severity of clinical findings and mortality percentages of challenged chickens with XDR S. Enteritidis confirming its pronounced antimicrobial activities. Moreover, thymol nanoemulsion, at this dose, had protective effects through up-regulation of the protective cytokines and down-regulation of XDR S. Enteritidis sopB virulence gene and interleukins (IL)-4 and IL-10 cytokines as those hinder the host defenses. Furthermore, it enhanced the growth of gut Bifidobacteria species, which increases the strength of the immune system. For that, we suggested the therapeutic use of thymol nanoemulsion against resistant foodborne pathogens. Finally, we recommended the use of 2.25% thymol nanoemulsion as a feed additive for immunocompromised individuals as well as in the veterinary fields.
Author Related Publications
Marwa Ibrahim Ibrahiem Abdelhamied, "Impact of Nigella sativa and Clove Oils on Cell Wall Genes Expression in Multidrug Resistant Staphylococcus aureus", Zagazig, Egypt, 2016
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Marwa Ibrahim Ibrahiem Abdelhamied, "Molecular Detection of Fluoroquinolone Resistance among Multidrug-, Extensively Drug-, and Pan-Drug-Resistant Campylobacter Species in Egypt", MDPI, 2022
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Marwa Ibrahim Ibrahiem Abdelhamied, "Thymol nanoemulsion promoted broiler chicken’s growth, gastrointestinal barrier and bacterial community and conferred protection against Salmonella Typhimurium", springer nature, 2021
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Marwa Ibrahim Ibrahiem Abdelhamied, "Supplementing Garlic Nanohydrogel Optimized Growth, Gastrointestinal Integrity and Economics and Ameliorated Necrotic Enteritis in Broiler Chickens Using a Clostridium perfringens Challenge Model", MDPI, 2021
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Marwa Ibrahim Ibrahiem Abdelhamied, "Interactive effects of dietary quercetin nanoparticles on growth, flesh antioxidant capacity and transcription of cytokines and Aeromonas hydrophila quorum sensing orchestrating genes in Nile tilapia (Oreochromis niloticus)", ELSEVIER, 2021
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Department Related Publications
Amal Anis Mahdi Eid, "): Infectious bronchitis virus infection in Egypt International Symposium on infectious bronchitis and pneumovirus ", لايوجد, 1900
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Ibrahiem Abdelrahman Ibrahiem Ghanem, "دراسات عن مرض الارانب النزيفي في مصر التغيرات الباثولوجيه للعدوي الطبيعيه والتجريبيه", لايوجد, 1900
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Ibrahiem Abdelrahman Ibrahiem Ghanem, ":دراسه مبدئيه لاستخام زيت حبه البركه في انتاج الدواجن", لايوجد, 1900
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Ibrahiem Abdelrahman Ibrahiem Ghanem, ":تغيرات ميكرو فلورا الامعاء في الدجاج البلدي أثناء الرقاد الطبيعي", لايوجد, 1900
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Ibrahiem Abdelrahman Ibrahiem Ghanem, ":دراسه عن مرض الارانب النزيف في محافظه الشرقيه", لايوجد, 1900
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