Recently, screen printing technology has attracted great attention in performing analytical applications with high reproducibility at a low cost. Therefore, potentiometric screen-printed electrodes (SPEs) were constructed for the quantitation of nicorandil (NIC) in its pharmaceutical formulations. Different ion-exchangers and plasticizers were investigated, but the optimal potentiometric response was obtained using nicorandil-phosphotungstate (NIC-PTA) ion associate and tricresyl phosphate as a plasticizer. A Nernstian response of 58.8±1 mV/decade was obtained over a concentration range of (1×10−6 - 1×10−2) M with 1×10−5 M as a detection limit. Sensor morphology was characterized using scanning electron microscopy (SEM). The method was validated for the assay of NIC with high selectivity, accuracy (average recovery=100.54%), and precision (%RSD ≤ 2).