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Smart UV spectrophotometric methods based on simple mathematical filtration and classical methods for the simultaneous determination of tamsulosin and solifenacin: A comparative study of efficacy and spectral resolution
Faculty
Pharmacy
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Soaad Selem Youssef Abdelhay
Staff Zu Site
Abstract In Staff Site
Journal:
SPECTROCHIMICA ACTA PART A-MOLECULAR AND BIOMOLECULAR SPECTROSCOPY ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS
Volume:
Keywords :
Smart , spectrophotometric methods based , simple mathematical
Abstract:
Treatment protocols combining tamsulosin and solifenacin proved better management of the complicated urinary tract symptoms. The pharmaceutical preparations of tamsulosin and solifenacin suffered from the high difference in their ratio, 0.4 mg tamsulosin and 6 mg solifenacin, and strong spectral overlap. Here, we developed four simple, accurate and selective spectrophotometric methods based on simple mathematical manipulations. These methods require the simplest mathematical filtration using short steps performed using built-in functions of the spectrophotometer operating software utilizing zero order or derivative spectra. These methods are namely absorption correction method (ACM), induced dual-wavelength (IDW), absorptivity factor method (AFM) and first derivative method (D1). The linear ranges were 15-70 ug/ml and 100-1200 ug/ml for TAM and SFN, respectively. The limits of quantitation were in the range of 3.8-4.05 ug/ml and 23.34-59.05 ug/ml, while the limits of detection were in the range of 1.25-1.34 ug/ml and 7.7-24.6 ug/ml for TAM and SFN, respectively. All validation parameters investigated as per ICH guidelines. A statistical comparison executed for the proposed methods with each other and with the reported methods showed no significant difference between the proposed and the reported methods. (C) 2020 Elsevier B.V. All rights reserved.
Author Related Publications
Soaad Selem Youssef Abdelhay, "Rp-HPLC Determination of Quercetin in a Novel D-alpha-Tocopherol Polyethylene Glycol 1000 Succinate Based SNEDDS Formulation: Pharmacokinetics in Rat Plasma", MDPIST ALBAN-ANLAGE 66, CH-4052 BASEL, SWITZERLAND, 2021
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Soaad Selem Youssef Abdelhay, "Application of quality by design approach for HPTLC simultaneous determination of amlodipine and celecoxib in presence of process-related impurity", ELSEVIERRADARWEG 29, 1043 NX AMSTERDAM, NETHERLANDS, 2021
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Soaad Selem Youssef Abdelhay, "Spectral analysis of severely overlapping spectra based on newly developed mathematical filtration techniques and ratio spectra manipulations: An application to the concurrent determination of dapoxetine and sildenafil in combined dosage form", PERGAMON-ELSEVIER SCIENCE LTD, 2021
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Soaad Selem Youssef Abdelhay, "Utilization of alizarin derivatives for thesensitive spectrophotometric determination of two proton pump inhibitors inpharmaceutical formulations", IOS, 2016
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Soaad Selem Youssef Abdelhay, "High performance liquid chromatography for simultaneous determination of xipamide, triamterene and hydrochlorothiazide in bulk drug samples and dosage forms", Croatian Pharmaceutical Society, 2016
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