The aim of the present study was to throw light on the clinical characteristics of vagal indigestion of cow calves and its related ruminal, hematobiochemical alterations and ultrasonographic findings. A total of 35 (25 male and 10 non-pregnant females) cow calves with vagal indigestion have been studied. The calves examined were aged 6-18 months. The affected animals were admitted to the clinic of Faculty of Veterinary Medicine, Zagazig University, Egypt. Ten apparently healthy cow calves were also included as control. The typical clinical symptoms were progressive abdominal distension resulting into papple shaped abdomen, dehydration and scanty feces. Ruminal fluid samples, blood samples were collected from all animals to estimate the ruminal changes and the hematological picture besides some of the selected biochemical parameters. Acidic pH “5.5-6” and high chloride concentration “> 30meq/L” were recorded in ruminal fluid analysis. Laboratory findings revealed a significant decrease in hemoglobin (Hb.) concentration and RBCs count and a significant increase in PCV and WBCs count in affected animals. There was a significant decrease in serum total protein and albumin levels, with a significant rise in serum globulin and fibrinogen levels. A 3.5 MHz linear transducer was used to assess the frequency, amplitude, duration and speed of the reticular contractions per two minutes while the animals were unsedated and in standing position. Ultrasonographically, the reticular motility were increased in 18 animals (4-8/2 minutes), decreased in 9 animals (< 2 contractions/2 minutes) and complete reticular atony was recorded in 8 animals. In control animals and those with vagal indigestion, the position, the contour and the size of the reticulum and the region surrounding the reticulum were not significantly different. In conclusion, VI is associated with characteristic clinical signs besides ruminal, hematobiochemical and ultrasonographic changes.