The renoprotective effect of glycyrrhizic acid in insulin-resistant rats exposed to aluminum involves the inhibition of TLR4/NF-κB signaling pathway

Faculty Pharmacy Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Journal: Naunyn-Schmiedeberg's Archives of Pharmacology Springer Berlin Heidelberg Volume:
Keywords : , renoprotective effect , glycyrrhizic acid , insulin-resistant rats    
Abstract:
الوصف Aluminum is well recognized as a nephrotoxic agent. Its hazardous effects arise from the high risk of daily exposure. The consumption of fructose also represents a critical health issue that might negatively impact different organs, including the kidneys. To pursue our previous work, this study aimed to investigate the potential renoprotective effects of glycyrrhizic acid (GLYA) on aluminum-induced nephrotoxicity in insulin-resistant rats. Insulin resistance (IR) was induced by adding fructose (10%) in drinking water for 18 weeks. Male Wistar rats were divided into five groups: control (CTRL), aluminum chloride (ALM, 34 mg/kg/day), fructose (FRCT), aluminum plus fructose (AL/FR), and GLYA (rats received AL/FR and treated with 40 mg/kg GLYA daily). AL/FR resulted in abnormal renal function tests and renal tissue injury. This was associated with increased oxidative stress and inflammation in the renal tissue
   
     
 
       

Author Related Publications

  • Mona Fouad Mahmoud Abdelaziz, "Anti-Inflammatory, Antipyretic, and Analgesic Properties of Potamogeton perfoliatus Extract: In Vitro and In Vivo Study", mdpi, 2021 More
  • Mona Fouad Mahmoud Abdelaziz, "Gastro-Protective Effects of Albizia anthelmintica Leaf Extract on Indomethacin-Induced Gastric Ulcer in Wistar Rats: In Silico and In Vivo Studies", mdpi, 2021 More
  • Mona Fouad Mahmoud Abdelaziz, "Syzygium samarangense leaf extract mitigates indomethacin-induced gastropathy via the NF-κB signaling pathway in rats", Elsevier, 2021 More
  • Mona Fouad Mahmoud Abdelaziz, "Syzygium jambos extract mitigates pancreatic oxidative stress, inflammation and apoptosis and modulates hepatic IRS-2/AKT/GLUT4 signaling pathway in streptozotocin-induced diabetic rats", Elsevier, 2021 More
  • Mona Fouad Mahmoud Abdelaziz, "Syzygium aqueum (Burm.f.) Alston Prevents Streptozotocin-Induced Pancreatic Beta Cells Damage via the TLR-4 Signaling Pathway", Frontiers, 2021 More

Department Related Publications

  • Hanan Hamdy Mahmoud Ibrahiem, "Study on the Molecular Mechanisms Involved Renal tissue injury", لايوجد, 1900 More
  • Rasha Hassan Abdelghani Hassan , "Effect of lansoprazole on gastric secretion, prostaglandin £2 and plasma", لايوجد, 1900 More
  • Nabila Noureldeen Mostafa Elmaraghy, "Pharmacological Studies on the possible Interactions between Some Analgesics", لايوجد, 1900 More
  • Hany Mohamed Abdelmalek Mahmoud ElBassossy, "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 More
  • Mohammed Nagieb Mohamed Zakarya Hassan , "Heme oxygenase-1 induction protects against hypertension associated with diabetes: effect on exaggerated vascular contractility", Naunyn-Schmiedeberg's Archives of Pharmacology, 2013 More
Tweet