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Synthesis, molecular modeling and anti-inflammatory screening of new 1,2,3-benzotriazinone derivatives
Faculty
Pharmacy
Year:
2012
Type of Publication:
Article
Pages:
4369-4380
Authors:
El-Feky, Said A, Abdel-Samii, Zakaria K, Ibrahim, Tarek S, Rashad, Adel A, Abdel-Hamid, Mohammed K, Barakat, Waleed
DOI:
10.1007/s00044-012-9975-3
Journal:
MEDICINAL CHEMISTRY RESEARCH SPRINGER BIRKHAUSER
Volume:
21
Research Area:
Pharmacology \& Pharmacy
ISSN
ISI:000310030200046
Keywords :
Synthesis, Benzotriazinone, Anti-inflammatory, COX-2
Abstract:
Several new 4(3H)-1,2,3-benzotriazinone derivatives were synthesized and tested for their anti-inflammatory activity and ulcerogenic effect. A docking study on the COX-2 binding pocket has been carried out for the target compounds to rationalize the possible selectivity. Among the tested compounds, the benzotriazinones linked to either thiadiazole (8) or oxadiazole (9) evoked the highest anti-inflammatory activity as well as the best binding profiles into the COX-2 binding site.
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