In the present work, thirteen reinforced concrete beams with openings at different locations were tested under four-point bending to investigate the efficiency of strengthening techniques of such openings. Different strengthening techniques around the opening were used before casting as internally reinforced by diagonal or upper and lower additional steel bars or after casting as externally bonded sheets of carbon fiber reinforced polymers (CFRP). The stiffness, mid-span deflection, maximum load, and failure mode of the strengthened beams were discussed. Experimental results showed that the best opening location is in the constant moment region around the neutral axis. The strengthening of such beam by internal reinforcements exhibited a higher ultimate load than that of the beam without opening. At the same time, the strengthening by external bonded CFRP failed to store the strength of such beam. The upper and lower additional steel bars technique is the best technique to restore the beam with the opening in midspan or beneath the applied load. The worst opening location is in shear span. The beam's strength with the opening in shear span was restored using CFRP, while internal reinforcement’s techniques failed. It can be concluded that the strengthening technique type depends on the opening location.