Daptomycin: A Novel Macrocyclic Antibiotic as a Chiral Selector in an Organic Polymer Monolithic Capillary for the Enantioselective Analysis of a Set of Pharmaceuticals

Faculty Pharmacy Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Sobhi Mohamed Mahmoud Ibrahym
Journal: molecules mdpi Volume:
Keywords : Daptomycin: , Novel Macrocyclic Antibiotic , , Chiral Selector , , Organic    
Abstract:
Daptomycin, a macrocyclic antibiotic, is here used as a new chiral selector in preparation of chiral stationary phase (CSP) in a recently prepared polymer monolithic capillary. The latter is prepared using the copolymerization of the monomers glycidyl methacrylate (GMA) and ethylene glycol dimethacrylate (EGDMA) in the presence of daptomycin in water. Under reversed phase conditions (RP), the prepared capillaries were tested for the enantioselective nanoliquid chromatographic separation of fifty of the racemic drugs of different pharmacological groups, such as adrenergic blockers, H1-blockers, NSAIDs, antifungal drugs, and others. Baseline separation was attained for many drugs under RP-HPLC. Daptomycin expands the horizon of chiral selectors in HPLC.
    
     
 
       

Author Related Publications

  • Sobhi Mohamed Mahmoud Ibrahym, "Analytical Chemical Studies on Certain Pharmaceutical Cerbonyl Compounds ", لايوجد, 1900 More
  • Sobhi Mohamed Mahmoud Ibrahym, "Determination of some Pharmaceutical Carbonyl Compounds", لايوجد, 1900 More
  • Sobhi Mohamed Mahmoud Ibrahym, "Targeting methionyl tRNA synthetase: design, synthesis and antibacterial activity against Clostridium difficile of novel 3-biaryl-N-benzylpropan-1-amine derivatives", taylor and francis online, 2016 More
  • Sobhi Mohamed Mahmoud Ibrahym, "40. Rapid RP-HPLC Method for Simultaneous Estimation of Norfloxacin and Tinidazole in Tablet Dosage Form. Mahmoud Sebaiy, Abdullah El-Shanawany,", Asian J. Pharm. Ana.,, 2011 More
  • Sobhi Mohamed Mahmoud Ibrahym, "42. Bromometric Estimation of Levofloxacin HCl, Lomefloxacin HCl and Sparfloxacin in Bulk and Dosage Forms.", Asian J. Res. Pharm. Sci, 2011 More

Department Related Publications

  • Abdallah Ahmed Abdallah Elshanawany, "Development and validation of liquid chromatographic method for simultaneous determination of amiloride hydrochloride and hydrochlorothiazide in human urine", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "HPLC Determination of polymyxin sulphate, Benzalkonium chloride, and gramicidine in pharm.formulation ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Synchronous Spectroflurimetric Determination of Famtidine,Fluconazole and Ketoconazole in bulk powder and in pharmaceutical dosages forms ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Synthesis of 3- substituted (6-bromo-2-imidazo{4,5-b}pyridinyl)propionic acid as antiinflammatory agents. ", لايوجد, 1900 More
  • Abdallah Ahmed Abdallah Elshanawany, "Application of difference spectrophotometry to the nitrosation reaction in the assay of certain antipyretic drugs . ", لايوجد, 1900 More
Tweet