Correlation between Apelin and Some Angiogenic Factors in the
Pathogenesis of Preeclampsia: Apelin-13 as Novel Drug for
Treating Preeclampsia and Its Physiological Effects on Placenta

Faculty	Science	Year:	2021
Type of Publication:	ZU Hosted	Pages:	ID 5017362, 12 pages
Authors:	Staff Zu Site Abstract In Staff Site
Journal:	Hindawi International Journal of Endocrinology Hindawi International Journal of Endocrinology	Volume:

Keywords :	Correlation between Apelin , Some Angiogenic Factors
Abstract:	+is study was formulated to assess the serum apelin level in PE, investigate its correlation with some inflammatory, oxidative stress, and angiogenic proteins in a nitric oxide synthase inhibitor; the N (gamma)- nitro-L-arginine methyl ester (L-NAME)-induced rat model of PE and determine whether apelin administration could protect against development of PE. 40 healthy adult female albino rats and 10 adult male albino rats were used in this study. +e pregnant female rats were randomly divided into three groups: group 1 (normal pregnant group), group 2 (PE-induced group), injected subcutaneously with 75 mg L-NAME/kg bodyweight/day starting from day 9 to 20 of gestation, and group 3 (PE-induced group supplemented with apelin (PE + apelin)); PE induced as before and simultaneously subcutaneously injected with apelin-13 (6 ×10−8 mol/kg bodyweight/twice daily) beginning from day 6 to 20 of gestation. In all groups, blood pressure and urine protein were determined at gestation days (GD) 0, 10, and 18.

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