Hyperlipidemia contributes to the emergence and development of circulatory diseases, which commonly causes morbidity and mortality. The present study evaluated the psyllium husk ethanolic extract (PHEE) effect on hyperlipidemia induced by Triton X-100. This study proved that Triton-induced hyperlipidemic rats with PHEE administration reduced hyperlipidemia by hepatic and pancreatic protective effects. The administration of PHEE lowered lipid peroxidation , increased antioxidant activity, and improved leptin and adiponectin hormone levels.