A new series of mixed ligand metal complexes has been synthesized by the reaction of Co(II), Ni(II), Cu(II), Zr(IV), Pd(II), and Cd(II) with norfloxacin (NOR) and metformin hydrochloride (MF) in 1 : 1 : 1 molar ratio. The complexes have been characterized by FT-IR, UV-Vis, and 1H NMR spectra, TG/DTG and elemental analysis, molar conductance, and magnetic susceptibility data. According to FT-IR, NOR chelates with metal ions as a bidentate ligand via one oxygen of the carboxylate group and pyridone oxygen, and MF chelates with metal ions via two imine groups. Complexes have been identified as electrolytes. Electronic and magnetic data have indicated the octahedral structure for all complexes except square planar Pd(II) complex. Antibacterial and antifungal activities of the compounds have been tested against several species, and have indicated higher inhibition against micro-organisms for the metal complexes than the mixed ligands.