Cobalt(II), copper(II), yttrium(III), zirconium(IV), lanthanum(III) and uranium(VI) complexes of 1,4-di(2-hydroxybenzylidene)thiosemicarbazide (H2L) were prepared and characterized. The proposed structures were determined from their elemental analyses, molar conductivities, magnetic moment, IR, Proton NMR, UVVis., mass spectra, X-ray diffraction and thermal analyses measurements. The high conductance data supply evidence for the electrolytic nature of the complexes. The changes in the selected bands in IR of Schiff base ligand upon coordination showed that Schiff base exhibits as a neutral tetradentate manner with oxygen and nitrogen donor sites. The complexes are thermally steady at room temperature and break up to two or three steps. The kinetic and thermodynamic parameters of complexes have been determined by using Coats-Redfern and Horowitz-Metzeger methods at n=1 and n≠1 and values suggest more ordered activated complex formation. The calculated bond length and force constant, F(U=O), in the uranyl complex are 1.744 Å and 664.886 Nm-1. The nematicidal activity of free Schiff base and all complexes were investigated and showed a low inhibition percentage (%I) of complexes compared with H2L.