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Meloxicam and Study of Their Antimicrobial Effects against Phyto- and Human Pathogens
Faculty
Science
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Sedik Attia Sedik Mohammed
Staff Zu Site
Abstract In Staff Site
Journal:
Molecules MDPI
Volume:
Keywords :
Meloxicam , Study , Their Antimicrobial Effects against Phyto-
Abstract:
Recently, the design of new biological metal-ligand complexes has gained a special interest all over the world. In this research, new series of mixed ligand complexes from meloxicam (H2mel) and glycine (Gly) were synthesized. Structures of the compounds were investigated employing elemental analyses, infrared, electronic absorption, 1H NMR, thermal analyses, effective magnetic moment and conductivity. The estimated molar conductivity of the compounds in 1 103 M DMF solution indicates the non-electrolyte existence of the examined complexes. Additionally, the effective magnetic moment values refer to the complexes found as octahedral molecular geometry. The data of the infrared spectra showed the chelation of H2mel and Gly with metal ions from amide oxygen and nitrogen of the thyizol groups of H2mel and through nitrogen of the amide group and oxygen of the carboxylic group for Gly. Thermal analyses indicated that the new complexes have good thermal stability and initially lose hydration water molecules followed by coordinated water molecules, Gly and H2mel. The kinetic parameters were calculated graphically using Coats–Redfern and Horowitz–Metzeger methods at n = 1 and n 6= 1. The density functional theory (DFT) calculations were performed at B3LYP levels. The optimized geometry of the ligand and its complexes were obtained based on the optimized structures. The data indicated that the complexes are soft with value in the range 0.114 to 0.086, while = 0.140 for free H2mel. The new prepared complexes were investigated as antibacterial and antifungal agents against some phyto- and human pathogens and the minimum inhibitory concentration (MIC) data showed that complex (A) has the lowest MIC for Listeria and E. coli (10.8 g/mL).
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Sedik Attia Sedik Mohammed, "First Report on Several NO-Donor Sets and Bidentate Schiff Base and Its Metal Complexes: Characterization and Antimicrobial Investigation", MDPI, 2023
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Sedik Attia Sedik Mohammed, "Synthesis and Spectral, Thermal and Antimicrobial Investigation ofMixed LigandMetal Complexes of N-Salicylidene Aniline and 1,10-Phenanthroline", MDPI, 2023
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Sedik Attia Sedik Mohammed, "Spectroscopic Investigation of New Schiff Base Metal Complexes", IJAR, 2014
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Sedik Attia Sedik Mohammed, "Spectroscopic, structural and antibacterial evaluation of some lomefloxacin metal complexes.", IJAR, 2014
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