Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Characterization of Foot and Mouth Disease Virus Serotype SAT-2 in Swamp Water Buffaloes (Bubalus bubalis) under the Egyptian Smallholder Production System
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Hend Mohamed Saad Abdulhamied
Staff Zu Site
Abstract In Staff Site
Journal:
Animals https://www.mdpi.com/journal/animals
Volume:
Keywords :
Characterization , Foot , Mouth Disease Virus Serotype SAT-2
Abstract:
Abstract: Spontaneous mutations are a common characteristic of the foot and mouth disease virus (FMDV), leading to wide antigenic variations resulting in the emergence of new topotypes and lineages of FMDV, which contributes to occasional vaccination failures. The objectives of the present study were to genetically characterize FMDV isolated from water buffaloes and study the biochemical and histopathological indicators of infected animals. Fifty-four water buffaloes of both sexes and different ages suffered from acute symptoms of FMD were clinically examined and randomly selected for inclusion in this study. Oral desquamated epithelial and oropharyngeal fluid samples have been tested for FMDV by reverse transcriptase PCR (RT-PCR). Tissue and serum samples were also collected from the diseased buffaloes and subjected to histopathological and biochemical analysis. Our findings showed that all examined samples were confirmed to be positive to FMDV serotype SAT-2 and were adjusted to be responsible for the recent disease outbreak in this study. Phylogenetic analysis revealed that the circulating viruses were of the SAT-2 serotype, closely related to the lineage of lib12, topotype VII, with 98.9% identity. The new lineage of SAT-2 showed a high virulence resulting in the deaths of water buffaloes due to heart failure, confirmed by high serum levels of inflammatory and cardiac markers, including haptoglobin, ceruloplasmin, cardiac troponin I and creatine phosphokinase-MB, indicating an unfavorable FMD-infection prognosis. In conclusion, we document the presence of new incursions circulating in water buffalo populations in Egypt in early 2019, explaining the high morbidity rate of FMD outbreak in early 2019. Furthermore, the newly identified serotype SAT-2 lib12 lineage, topotype VII, showed an aggressive pattern in water buffaloes of the smallholder production system.
Author Related Publications
Hend Mohamed Saad Abdulhamied, "Diagnostic performance of molecular and conventional methods for identification of dermatophyte species from clinically infected Arabian horses in Egypt", Vet Dermatol, 2016
More
Hend Mohamed Saad Abdulhamied, "Species Identification, Strain Differentiation, and Antifungal Susceptibility of Dermatophyte Species Isolated From Clinically Infected Arabian Horses", Journal of Equine Veterinary Science, 2017
More
Hend Mohamed Saad Abdulhamied, "Strangles in Arabian Horses in Egypt: Clinical, epidemiological, hematological and biochemical aspects", Veterinary World, 2016; 9(8): 820-826, 2016
More
Hend Mohamed Saad Abdulhamied, "Epidemiological and Ultrasonographic investigation of Bovine Fascioliasis in Smallholder Production System in EasternNile Delta of Egypt", Preventive veterinary medicine journal , 158 (2018) 35–42, 2018
More
Hend Mohamed Saad Abdulhamied, "Clinical Mastitis in Sheep Smallholder System in Sharkia Province Bacteriological Studies, In Vitro Antibiogram Profile and Mineral Picture", Advances in Environmental Biology,2018 12(4): 6-11., 2018
More
Department Related Publications
Ahmed Mahmoud Wasfi Elkabany , "فصل مكونات بروتين السيرم في عجول الجاموس حديثة الولاده المصابه بالاسهال بواسطة الالكتروفوريزس ( التثريد الكهربي )", لايوجد, 1900
More
Ahmed Mahmoud Wasfi Elkabany , " تقرير عن حاله مرضيه", لايوجد, 1900
More
Hatem Mohamed Sleim Mouhamd, "دراسات حقليه عن الكبريت والفلورين المتطاير وأثرهما على بعض الحيوانات المجترة .", لايوجد, 1900
More
Hamed Attia Mohamed Sayed, "دراسات حقلية عن الاسهال فى مهارى الخيل ", لايوجد, 1900
More
Hamed Attia Mohamed Sayed, "دراسات اكلينيكية ومعملية على المشاكل الرئوية فى العجول الفريزيان فى الستة أشهر الأولى من العمر ", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف