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Could local curative breast surgery improve survival in women with oligometastatic breast cancer?
Faculty
Medicine
Year:
2020
Type of Publication:
ZU Hosted
Pages:
Authors:
Loay Mohammed Hadi Osman
Staff Zu Site
Abstract In Staff Site
Journal:
The Egyptian Journal of Surgery The Egyptian Journal of Surgery
Volume:
Keywords :
Could local curative breast surgery improve
Abstract:
Patients who initially present with a few metastatic lesions from breast cancer are termed as having oligometastatic disease (OMD). The long-term OMD survivors are young patients with a good performance status. Recently, there has been an improvement in systemic and hormonal therapy which could improve patients’ outcome. However, the roles of surgical management of the primary tumor for patients with OMD still need clarifications. Aim The aim was to evaluate treatment effects and patient outcome of surgical excision of the primary tumor in patients with cancer breast, who were initially presented with OMD. Patients and methods This study included 60 patients with breast cancer with OMD. Patients included in our study were divided into three groups, and each group included 20 patients: first, the first group underwent systemic therapy before surgery; second, the second group underwent surgery before systemic therapy; and third, the third group underwent systemic therapy alone. The authors followed all patients for ∼3 years and identified survival rates and patients outcome. Results Young patients underwent surgery more often than old patients after systemic therapy (P=0.006). There is a statistically significant difference between the studied groups regarding recurrence (P=0.038), death (P=0.017), recurrence-free survival (P<0.001), and overall survival (P=0.003). The group that underwent combined surgery and systemic therapy had the most significant longer recurrence-free and overall survival rates. Conclusions Surgical removal of the primary tumor has a curative role in patients with breast cancer with OMD, and it improves patients’ outcome and survival rates.
Author Related Publications
Loay Mohammed Hadi Osman, "Panel of Villin, Pro-Ex-C, Estrogen Receptor and Progesterone Receptor Expressions Could Help in Differentiation Between Endocervical and Endometrioid Adenocarcinoma", Turkish journal of pathology, 2017
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Loay Mohammed Hadi Osman, "Immunohistochemical expressions of SQSTM1/p62, Beclin-1, and SOX4 in infiltrating duct carcinoma of the breast", Egyptian Journal of Pathology, 2016
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Loay Mohammed Hadi Osman, "Invasive primary papillary carcinoma in a thyroglossal duct cyst: A case report and review of the literature", Elsevier, 2018
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Loay Mohammed Hadi Osman, "The Expression of FOXE-1 and STIP-1 in Papillary Thyroid Carcinoma and Their Relationship with Patient Prognosis", Iran J Pathol.2018, 2018
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Loay Mohammed Hadi Osman, "SPOP, ZEB-1 and E-cadherin expression in clear cell renal cellcarcinoma (cc-RCC): Clinicopathological and prognostic significance", Elsevier, 2018
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Department Related Publications
Ahmed Alsayed Ahmed Lashen, "تصليح الفتق الاربى " محاولة اليجاد طريقة جديدة", لايوجد, 1900
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Ahmed Mosaad Ibrahiem Nagieb, "افرازات حلمة الثدي اهمية العينة الجرالحية لحالات افرازات حلمة الثدي ذات القيمة الجراحية", لايوجد, 1900
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Ahmed Mosaad Ibrahiem Nagieb, "استئصال القناه الابنه بسبب افراز من قناة بجملة الثدي باستعمال طريقة جراحية جديدة لتحديد بواسطة الحقن وعادة افيدون ", لايوجد, 1900
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Ahmed Mosaad Ibrahiem Nagieb, "تشخيص التهاب الزائدة الدودية بالتصوير الفوق صوتي ومقارنة بالواحدة السريرية والمعطيات الجراحية", لايوجد, 1900
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Osama Hassan Ghareeb Ibrahiem, "دراسة مقارنة بين طريقة بوجوتا وطريقة الشفط مع الحشرى فى علاج متلازمة المتجزئة الباطنية الناتجة من ارتفاع الضغط داخل البطن", لايوجد, 1900
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