The current research aims to establish the relationship between general self-efficacy and both of (spiritual intelligence- goal orientation), and to verify that there are differences between (general self- efficacy - spiritual intelligence- goal orientation) according to demographic variables: sex (male/female), specialization (scientific/literary), and domicile (rural/city), as well as Predicting general self-efficacy from spiritual intelligence and its dimensions, as well as general self-efficacy from goal orientation and its various dimensions, and verifying the possibility of mediating spiritual intelligence the relationship between goal orientation and general self-efficacy, There were (169) students from Zagazig University; The goal is to calculate the reliability and validity of the research tools, which are the "General Self-Efficacy Scale, Spiritual Intelligence scale, Goal Orientation Scale". The final sample was (640) students from Zagazig University, who were selected randomly; to verify research hypotheses, the statistical methods used were the Pearson’s correlation coefficient, the (t) test, the analysis of multiple Regression, and simple Mediation analysis, The most important results indicated that there is a positive correlation between general self-efficacy and spiritual intelligence in all its dimensions and overall score, and goal orientation in all its dimensions and overall score. There are significant differences in (critical existential thinking) as a dimension of spiritual intelligence for the students of the (scientific) specialization, we can predict the general self-efficacy from three dimensions of spiritual intelligence, and from various dimensions of goal orientation, Finally, spiritual intelligence mediates the relationship between goal orientation and general self-efficacy.