Efficient utilization of waste heat to run a power and desalination systems is a key technology to mitigate the energy-water crisis. Organic Rankine Cycle (ORC) is one of the promising systems that can exploit low-grade waste heat. So, this paper introduces a novel ORC-based poly-generation system driven by waste heat to produce electrical, cooling, and heating power. The poly-generation system is integrated with multi-effect desalination (MED) system for freshwater production as well. Energy, exergy, and exergo-economic (3E) investigations are made to assess the feasibility of integration of the proposed novel ORC to MED cycle. The new ORC has an adjustable three-way valve to control the seasonal requirement of electrical, heating, and cooling power. Performance of the suggested multi-generation ORC/MED is evaluated by calculating the plant electrical efficiency (η elec), energy utilization factor (E U F …