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Ameliorative Effect of Thymoquinone-Loaded PLGA Nanoparticles on Chronic Lung Injury Induced by Repetitive Intratracheal Instillation of Lipopolysaccharide in Rats
Faculty
Veterinary Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
1-12
Authors:
Abdelmoneim Ahmed Ali Muhmmed
Staff Zu Site
Abstract In Staff Site
Journal:
Oxidative Medicine and Cellular Longevity Hindawi
Volume:
5511523
Keywords :
Ameliorative Effect , Thymoquinone-Loaded PLGA Nanoparticles , Chronic
Abstract:
Thymoquinone (TQ), the active constituent of Nigella sativa, possesses several benefits in traditional and modern medicines. This study examined the effect of a single dose of Nano-TQ on chronic lung injury induced by repetitive intratracheal installation of lipopolysaccharide (LPS). Rats received LPS twice weekly for 8 weeks via intratracheal installation and a single dose of TQ-PLGA NPs on the day after the last dose of LPS. Six rats from each group were sacrificed after 8 and 10 weeks, and samples were collected for analysis. Repetitive intratracheal installation of LPS caused histopathological alterations, including partial or complete obstruction of the alveoli, interstitial edema, mild fibroblastic proliferation, fibrous strands besides lymphocytes and plasma infiltrations, suffered fetalization, bronchiectasis, hypertrophied arterioles, and others. Investigation of the ultrastructure revealed prominent necrotic pneumocytes with destructed chromatin and remnant of necrotic debris in the narrowing alveolar lumen in LPS-induced rats. TQ-PLGA NPs effectively ameliorated LPS-induced histopathological and ultrastructural alterations in the lung of rats. In addition, TQ-PLGA NPs significantly alleviated serum levels of IL-10 and TGF-β1 in LPS-induced rats. In conclusion, TQ-PLGA NPs prevented inflammation and tissue injury in the lungs of rats challenged with repetitive intratracheal installation of LPS. Therefore, TQ-PLGA NPs represent a promising candidate for the prevention of lung injury induced by LPS, pending further studies to determine its safety and exact protective mechanism. © 2021 Sultan A. M. Saghir et al.
Author Related Publications
Abdelmoneim Ahmed Ali Muhmmed, "Ocular squmaous cell carcinoma in an Arabian mare", Zagazig Vet. J. Vol. 16. No. 4, 1988
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Abdelmoneim Ahmed Ali Muhmmed, "Histopathological on the genital organs experimentally exposed to the sub anaesthatic doses of isoflurane and enflurane", Zagazig Med.Ass, 1990
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Abdelmoneim Ahmed Ali Muhmmed, "Preliminary studies on vibriosis in some fresh water fishes", Zagazig Vet. J. Vol. 18. No. 5, 1990
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Abdelmoneim Ahmed Ali Muhmmed, "Studies on tuberculosis in cattle at Sharkia province", Second. Vet. Med. Con. Zagazig, 1994
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Abdelmoneim Ahmed Ali Muhmmed, "Pathogenicity of recent isolates of pigeon paramyxovirus in pigeons in Egypt", Vet. Med. J. Giza 43,No.2, 1995
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Department Related Publications
Alsayed Rashad Abdelmegeed , "عدوى الدودة الحلزونية وتوكساكارا كانز فى خنازير غينيا", لايوجد, 1900
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Abdallah Alsayed Morssy, "pathological studies on cancer prevention in albino rats. ", لايوجد, 1900
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Abdallah Alsayed Morssy, "- Diagnostic Studies on Infertility of Bufflo- Cows with Uterine Infection (2005):", لايوجد, 1900
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Abdallah Alsayed Morssy, "The effect of endoxan injection on rats with special references to pregnancy.", لايوجد, 1900
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Abdallah Alsayed Morssy, "Sternal fibromatosis in the dromedary camel.", لايوجد, 1900
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