The phytotoxicity of heavy metals released through anthropogenic activities conclusively reduces crops growth and productivity. The current study was carried out to assess the effect of some heavy metals (zinc [Zn], lead [Pb] and cadmium [Cd]) and their mixture on growth of eight wheat genotypes in early stage under laboratory conditions. The results showed that the heavy metals significantly reduced germination percentage, root and shoot growth. Zn had the least negative effect, while mixture of the three elements had themost drastic effect followed by Cd and then Pb. Wheat genotypes varied in their response to heavy metal stress. Moreover, it could be concluded that wheat genotype Gemmeiza-11 had the maximum tolerance against Zn, Pb, Cd and theirmixture followed byMisr-1 and Sids-12, while, Sids-13 and Gemmeiza-9 displayed the lowest tolerance. The tolerant genotypes in early growth stages could be used commercially under heavy metals stress as well as could be utilized as donors for developing promise cultivars destined for agricultural production under heavy metals stress