Abstract Healthcare organizations, because of their distinctive structure and management conduct, vary from other institutions. The organizational climate is the main building blocks for organizations that promote innovation. This research aimed to explore the relationship between leadership behaviors, organizational climate, and innovative work behavior among nurses at Zagazig University Hospitals, Egypt. A descriptive correlation design has been used for this study. From the above-mentioned settings' a stratified random sample of 384 nurses was selected. A questionnaire sheet was used to obtain information for this research, which consisted of three tools: I. Modified multifactor leadership behaviors questionnaire, II. Organizational climate questionnaire, and III. Modified innovative work behavior questionnaire. Results indicated that 83.9 % of nurses had a positive perception of transformational leadership behavior. On the other side, 81% of nurses had a positive organizational climate perception. Likewise, 49.2% of nurses had a high level of innovative work behavior. Furthermore, the organizational climate was highly significantly and positively correlated to laissez-faire leadership behavior, where p-value < 0.001. Besides, there were significant and positive correlations between innovative work behavior as regards all multifactor leadership behaviors and organizational climate. Conclusion: Transformational leadership was the most influential and predictor type of innovative work behavior. Besides, there was a significant and positive correlation between organizational climate and innovative work behavior. Recommendation: To conduct a workshop on creative thinking and design approaches to enhance the behavior of innovation among nurses and promote it.