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I.p.-injected cationic liposomes are retained and accumulate in peritoneally disseminated tumors
Faculty
Pharmacy
Year:
2022
Type of Publication:
ZU Hosted
Pages:
Authors:
Amr Selim Ahmed Ali Abu Lila
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Controlled Release ELSEVIER
Volume:
Keywords :
I.p.-injected cationic liposomes , retained , accumulate , peritoneally
Abstract:
Intraperitoneal (i.p) chemotherapy is an attractive approach to treat peritoneally disseminated cancers by delivering therapeutic agents directly to the peritoneal cavity where some disseminated tumors are located. Cationic liposomes (CLs) have been used as a viable delivery carrier for i.p. chemotherapy to improve the peritoneal retention of anticancer agents. However, there are no reports on the fate of CLs following i.p. administration to the peritoneal cavity in the presence of disseminated tumors. We prepared a tumor xenograft murine model of peritoneally disseminated gastric cancer by i.p. inoculation of human gastric cancer cells and followed the fate of either CLs or PEGylated CLs (PEG-CLs) after i.p. injection in the model. I.p.-injected CLs were retained in peritoneal cavity for at least 3 days post-injection as a result of clustering with ascites fluid proteins, mainly albumin, while i.p. PEG-CLs was rapidly cleared from the peritoneal cavity to the circulation within 3 h post-injection. Importantly, i.p. CLs efficiently accumulated in the targeted disseminated tumor cells, but not in other abdominal organs including liver, spleen, and kidney. The tumor selectivity upon i.p. administration of CLs may be associated with the lymphatic drainage system. A lipoplex formulation composed of CLs with short hairpin RNA (shRNA) against luciferase, a model therapeutic agent, suppressed luciferase activity in peritoneally disseminated tumors by 80%, with no cytokine secretion in serum. This suggests that i.p. CLs can efficiently deliver a therapeutic agent to peritoneally disseminated tumors with few systemic adverse events. These results suggest that i.p. treatment with CLs or non-PEGylated lipoplexes may be a promising approach for the treatment of peritoneally disseminated cancers through their ability to selectively deliver therapeutic agents to i.p. target sites with minimal systemic adverse events.
Author Related Publications
Amr Selim Ahmed Ali Abu Lila, "Activation of TLR9 by incorporated pDNA within PEG-coated lipoplex enhances anti-PEG IgM production", nature, 2014
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Amr Selim Ahmed Ali Abu Lila, "Treatment of pulmonary arterial hypertension by vardenafil-solid dispersion lozenges as a potential alternative drug delivery system", Elsevier, 2020
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Amr Selim Ahmed Ali Abu Lila, "Doxorubicin Embedded into Nanofibrillated Bacterial Cellulose (NFBC) Produces a Promising Therapeutic Outcome for Peritoneally Metastatic Gastric Cancer in Mice Models via Intraperitoneal Direct Injection", MDPI, 2021
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Amr Selim Ahmed Ali Abu Lila, "Efficacy of SPG-ODN 1826 Nanovehicles in Inducing M1 Phenotype through TLR-9 Activation in Murine Alveolar J774A.1 Cells: Plausible Nano-Immunotherapy for Lung Carcinoma", MDPI, 2021
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Amr Selim Ahmed Ali Abu Lila, "Not Only Antimicrobial: Metronidazole Mitigates the Virulence of Proteus mirabilis Isolated from Macerated Diabetic Foot Ulcer", MDPI, 2021
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Department Related Publications
Ahmed Samer Zedan, "Physicochemical characterization and dissolution properties of rofecoxib complexes with cyclodextrins", لايوجد, 1900
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Ahmed Samer Zedan, "Preparation and characterization of rofecoxib solid dispersions with polyethylene glycols and urea", لايوجد, 1900
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Mahmoud Mokhtar AhmedIbrahiem, "Effect of some formulation parameters on flurbiprofen encapsulation and release rates of niosomes prepared from proniosomes", لايوجد, 1900
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Amr Selim Ahmed Ali Abu Lila, "Use of polyglycerol (PG), instead of polyethylene glycol (PEG), prevents induction of the accelerated blood clearance phenomenon against long-circulating liposomes upon repeated administration", Elsevier, 2013
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Amr Selim Ahmed Ali Abu Lila, "Tumor-type-dependent vascular permeability constitutes a potential impediment to the therapeutic efficacy of liposomal oxaliplatin", Elsevier, 2012
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