The purpose of this paper is to develop a framework for managing wastes resulting from the restoration works in historic Cairo, Egypt. To achieve the abovementioned aim, a research methodology was designed to accomplish four objectives. Firstly, a literature review was used to investigate the nature of historic buildings, and national and international experiences of managing restoration waste. Secondly, 43 case studies from historic Cairo were used to identify the most common practices for managing building restoration waste. Thirdly, a survey questionnaire was conducted with experts to evaluate the most sustainable indicators of assessing building material waste. Finally, a framework was developed to facilitate the management of buildings’ restoration waste in historic Cairo. Moreover, it concludes the most important factors of buildings’ materials waste management in historic Cairo. The research discusses the importance of historic buildings and their status of ignorance and obsoleteness. In addition, it highlights the deficiencies of the waste management system. Furthermore, it presents a framework to manage waste resulting from restoration work on the buildings of historic Cairo, which represents a synthesis that is novel and creative in thought and adds value to the knowledge in a new way.