Cytokine Storm in COVID-19 Patients: Association between cytokines and disease severity

Faculty Medicine Year: 2021
Type of Publication: ZU Hosted Pages:
Authors:
Walaa Mohamed Ibrahim Sarhan
Journal: ZUMJ EKB Volume:
Keywords : Cytokine Storm , COVID-19 Patients: Association between    
Abstract:
Objectives: To determine the cytokine storm profile in patients with COVID-19 infection in relation to the disease severity. Methods: Serum levels of TNF-α, IFN-γ, IL-6 and IL-1β were measured by ELISA method and IL-1RII, TNFR1 and TNFR2 gene expression in peripheral blood mononuclear cells (PBMCs) were done using real time polymerase chain reaction (PCR) method in a total of 203 COVID-19 patients. The 1st group included 52 COVID-19 severe cases, the 2nd comprised 104 moderate cases and the 47 mild cases lied in the 3rd group. Results: There was a significant association between degree of COVID-19 severity and IL6, TNF-α & IFN-γ serum levels (p < /p>
    
     
 
       

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