Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Association between CD4+, CD25+, FOXP3+ Regulatory T-cells and Cardiovascular Complications in Diabetic Patients Type 1
Faculty
Medicine
Year:
2019
Type of Publication:
ZU Hosted
Pages:
Authors:
Reham Mohamed Elshabrawi Mohamed
Staff Zu Site
Abstract In Staff Site
Journal:
Egyptian Journal of Immunology Egyptian society of Immunology
Volume:
Keywords :
Association between CD4+, CD25+, FOXP3+ Regulatory
Abstract:
tory cells (Tregs) are a cornerstone regulator for immune responses and inflammatory reactions. Abnormal number or function of Tregs causes deranged immune response that increases the autoimmune disorders and inflammatory conditions. Type 1 diabetes mellitus is an autoimmune disease associated with many complications, of which, Cardiovascular complications are fundamental and responsible for profound morbidity and mortality. Understanding the immunopathogenesis of these disorders allows early diagnosis and better management by innovating new therapeutic targets. In this study, we aimed to detect the association between CD4+CD8+FOX3+ Tregs, T1DM, and associated cardiovascular complications. The study included 144 individuals divided into three groups, group 1 included 48 patients suffering from T1DM without cardiovascular complications, group II: included 48 type T1DM patients with cardiovascular complications. Group III: included 48 healthy control subjects. For all participants, markers for inflammation, and cardiovascular involvement were assessed. The percentage of CD4+ CD25+ FOXP3+ Regulatory T- cells (Tregs) was measured by flow cytometry using peripheral blood samples. The level of Treg was lowest in group II and highest in group III, the difference was highly significant P<0.001. Treg in group I significantly correlated with age (r= 0.58, P=0.004), CK-mb (r= 0.61, P=0.04) and LDL (r= -.61, P=0.4). While in group II, it correlated with triglyceride level, (r= 0.65 and a P =- 0.02). In conclusion, Lower levels of Tregs are associated with cardiovascular complications in TIDM patients.
Author Related Publications
Reham Mohamed Elshabrawi Mohamed, "Serum Levels of Transforming Growth Factor Beta -1 (TGF-β1) as An Early No Invasive Marker for Diagnosis of Lupus Nephritis in Systemic Lupus Erythematosus Patients", Egyptian society of Immunologyy, 2019
More
Reham Mohamed Elshabrawi Mohamed, "Patterns of sensitization to food allergens among allergic adults and children following-up in Zagazig university hospitals, Egypt", Egypt Society of Pediatr Allergy Immunol, 2021
More
Reham Mohamed Elshabrawi Mohamed, "عنوان البحث Allergy and hematological malignancies risk: A possible implication of Immunoglobulin E, TNF-α and Interleukin 10", The Egyptian Society of Immunology, 2021
More
Reham Mohamed Elshabrawi Mohamed, "Interferon-gamma Expression Profile as Diagnostic Signatures of Unexplained Infertility in Female Patients Suffer from Hashimoto's Thyroiditis", Iran Society Allergy Asthma Immunol, 2021
More
Reham Mohamed Elshabrawi Mohamed, "The effect of food elimination and probiotic supplementation in asthmatic children with food allergy", Egyptian Society of allergy and Immunoligy, 2021
More
Department Related Publications
Noha Mohamed El Sayed Hammad, "The incidence of Mycoplasma pneumoniae in community acquired pneumonia among children: one centre study", Microbes and Infectious diseases, 2020
More
Noha Mohamed El Sayed Hammad, "Complement component 3c and tumor necrosis factor-α systemic assessment after Candida antigen immunotherapy in cutaneous", Brazilian Journal of Microbiology, 2020
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف