Background: Dermatofibrosarcoma protuberans (DFSP) is a rare, indolent, low-grade sarcoma recognized as progressive locally infiltrative nature, and it is much less frequent than desmoid tumor. It accounts for <0.1% of all cutaneous malignancies and 6% of all soft-tissue sarcomas. A painless, long-standing, slow-growing cutaneous nodule remains the most common form of presentation of this disease. Patients and Methods: Sixteen patients with DFSP (9 patients; Group A) were recurrent, of them three patients had recurrence of the disease for the 4th time, and seven patients (Group B) were dealt with for the 1st time. Results: Nine recurrent tumor patients had operated with 5-cm safety margin and were followed up for more than 2 years after postoperative radiation therapy, none of them had recurrence. Seven nonrecurrent cases were operated with 3 cm safety margin and followed up for 1–3 years after postoperative radiation therapy, none of them had recurrence. Conclusion: Excision of DFSP with enough safety margin followed by radiation therapy decreases the rate of recurrence; however, long-term follow-up and further studies are required.