n countries like Saudi Arabia where multiple nationalities are present in the same place, the rare and uncommon diseases are to be considered. In this study we recorded the real incidence of different types of GIT tumors among 100 cases. Patients and Methods: From January 2014- January 2016, a retrospective study included one hundred patients suffering from GIT malignant tumors admitted to Hospital of Zagazig University, Cairo University and Saudi-German Hospital, Jeddah. We exclude esophagus and anal canal tumors. Results: Among 100 cases of different types and different sites of GIT malignant tumors, 42 cases (42%) were colorectal, 14 cases (14%) were gastric, 12 cases (12%) were pancreatic, 8 cases (8%) were hepato-biliary. Their ages were averaged 52 ± 13 years, ranged from 17-88 years old. The cases included both males and females in a ration of 1.7-1.0. The average duration of the presenting symptoms was 4 months. In nearly 87% of operated cases, the tumors were resected. The histopathology in 82% of operated cases showed a predominance of adenocarcinomas. Conclusions: This study underlines the existence, within the GIT malignant tumors, of many different entities with various clinical and pathological forms and prognosis, whose detection is essential for choosing suitable therapeutic approach.