Abstract: In the current study, we tried to evaluate the levels the T-helper-1 (TH-1) cytokine IFN-gamma (IFN- γ) and the TH2 cytokines (IL-4, IL-10 and IL-13) in both peripheral blood mononuclear cell culture (PBMC) following in vitro stimulation with Schistosoma soluble egg antigen (SEA) and serum of patients infected with S. mansoni and their relation to hepatic fibrosis induced by S. mansoni. Thirty-one S. mansoni infected individuals with and without liver fibrosis were analyzed for cytokine profiles. According to ultrasound evaluation of liver fibrosis, our study subjects were classified into Group 0, Group I, Group II, and Group III. Cytokines were measured in S. mansoni Soluble egg antigens (SEAs) stimulated whole blood culture supernatants and serum using commercial kits. Subjects in the hepatic fibrosis groups showed significant increase in IFN- γ, IL-10, and IL-13 (p<0.05) in comparison to non-fibrotic group. On the other hand, IL-4 was non-significantly elevated in the fibrosis group in comparison to the nonfibrotic group (p >0.05). Our results suggest that high serum and blood culture level of IL-13 recorded in fibrotic patients is associated with development of Schistosoma mansoni induced liver fibrosis.