Background:Renal cell carcinoma(RCC) is the most common malignancy of the kidney.Snail is a zinc-finger transcription factor, associated with advanced tumor stage and poor prognosis of RCC.Insulin-like mRNA-binding protein3 (MP3) immunopositivity predicts metastatic progression and patients’ survival in RCC. Aldehyde dehydrogenase 1(ALDH1) is a stem cell marker, expressed in many different solid tumors of bladder, pancreas, colon and kidney. The aim of this study is to assess the diagnostic value of Snail, IMP3 and ALDH1 immunoexpressioninclear cell, papillary and chromophobe variants of RCC. Method:This retrospective study included 50 tissue blocks of RCCcases (35 clear cell,11 papillary and 4 chromphobe carcinomas). Immunohistochemical staining using antibody against Snail, IMP3 and ALDH1 were evaluated in all cases Results:Snail was observed in (74.3%) clear cell RCC, (18.2%) papillary but negatively expressed in all chromophobe carcinoma.IMP3 was expressed in 72.7% of papillary carcinoma, 28.6% of clear cell RCC and it was totally expressed in all chromophobe carcinoma. ALDH1 was 94.2% of clear cell RCC (54.6%) in papillary carcinoma and in 50% of chromphobe carcinoma. Snail, IMP3 and ALDH Lassociatedwith advanced tumor stage and high grade, so considered poor markers for renal cell carcinoma patients. Conclusion: ALDH1 is agood sensitive marker for diagnosis of renal cell carcinoma especially clear cell type while IMP3 is a good marker for diagnosis of chromophobe carcinoma and Snail can be used for diagnosis of clear cell carcinoma.