Evaluation of the Curative and Protective Role of Fresh Chicory Juice in Treatment of Hepatic Fibrosis in Male Albino Rats

Faculty Science Year: 2021
Type of Publication: ZU Hosted Pages: 1331-1343
Authors:
Journal: Biomedical & Pharmacology Journal, September 2021 Scoups Volume: 14
Keywords : Evaluation , , Curative , Protective Role , Fresh Chicory Juice    
Abstract:
Using synthetic drugs for treating liver fibrosis remains a challenge since, in contrast to natural products, are remarkably expensive and associated with several adverse effects. Herbs and plants showed strong antioxidant, anti-inflammatory, and antimicrobial properties. To investigate the hepatoprotective role of fresh chicory juice in delaying the immune response of hepatic cells to Carbon tetrachloride [CCl4]-induced fibrosis. Fresh chicory plant juice [50%] was given instead of drinking water to male albino rats [150-200 g]. Blood samples were collected for biochemical evaluation of liver and kidney function, antioxidant markers, lipid profile, and gene expression of TGF-ß by quantitative real-time quantification polymerase chain reaction [q PCR]. Liver tissue was removed and subjected to histopathological and genomic DNA fragmentation assay. Measurements of liver enzymes, kidney function, lipid profile and levels of antioxidants confirmed the ability of chicory to protect the liver against CCl4-induced liver fibrosis by acting as a good inhibitor of TGF-ß. These results were confirmed by histopathological examination and DNA fragmentation. Administration of fresh chicory juice [50%] showed a significant protective role of chicory plant in delaying CCl4-induced liver fibrosis by decreasing TGF-ß.
   
     
 
       

Author Related Publications

  • Ahmed Heussein Mostafa, "Efficient biocontrol of Spodoptera littoralis by Aspergillus nidulans, an endophyte of Lantana camara", ٍSpringer, 2020 More
  • Ahmed Heussein Mostafa, "Synthesis and Biological Evaluation of Glycosides and AcyclicNucleosides Derived 2-Oxonicotinonitriles", Wiely, 2019 More
  • Ahmed Heussein Mostafa, "Novel Triazole-, Oxadiazole-, and Pyrazole-Nicotinonitrile Hybrids: Synthesis, DFT Study, Molecular Docking, and Antimicrobial Activity", ٍSpringer, 2022 More
  • Ahmed Heussein Mostafa, "Synthesis and biological evaluation of 2-Oxo/thioxoquinoxaline and 2-Oxo/thioxoquinoxaline-based nucleoside analogues", EBSCO, 2016 More
  • Ahmed Heussein Mostafa, "Synthesis, Antiviral, and Antimicrobial Activity of N- and S-Alkylated Phthalazine Derivatives", Wiley, 2016 More

Department Related Publications

  • Hassan AbdelFattah Mohammed, "Design and synthesis of some tricyclic pyrimidines and triazines via cycloaddition and intermolecular cyclization of cyclic amidine", Springer, 2017 More
  • Mohamed Yousry Elsayed ebrahim, "Synthesis of new drug model has an effective antimicrobial and antitumors by combination of cephalosprin antibiotic drug with silver (I) ion in nano scale range: chemical, physical and biological studies", Elsevier, 2017 More
  • Amr Lotfy Saber Hefny, "Liquid Chromatographic and Potentiometric Methods for the Determination of Oxomemazine in Pharmaceutical Preparations", Open Science, 2017 More
  • Hassan AbdelFattah Mohammed, "O-glycosylation/alkylation and antimicrobial activity of 4,6-diaryl-2-oxonicotinonitrile derivatives", Wilyinterscience, 2017 More
  • Reda Ahmed aly Hjam, "O-glycosylation/alkylation and antimicrobial activity of 4,6-diaryl-2-oxonicotinonitrile derivatives", Wilyinterscience, 2017 More
Tweet