The silkworm is an eco-friendly, beneficial, and economic insect reared for the production of silk. This study was carried out to estimate some physiological aspects by Feeding of mulberry silkworm larvae at the 4th and 5th instar with mulberry leaves sprayed with different concentrations of ethanolic extract of Terminalia chebula and oil of Simmondsia chinensis. Founding that, during the 4 th instar, the highest means of total soluble proteins, total carbohydrates, total lipid, and aminotransferases enzymes (ALT and AST) are 1.991g/dl, 193.391µg/ml, 1807mg/ml, and (4.46 and 4.38 u/l), respectively. During the 5th instar, the highest means for the same consequence were 1.965g/dl,168.174 µg/ml, 1660 mg/dl, and (3.93 and 4.51 u/l). Jojoba oil recorded higher values than Black myrobalan, Both Black myrobalan and Jojoba oil enhanced the measured physiological aspects.