Zagazig University Digital Repository
Home
Thesis & Publications
All Contents
Publications
Thesis
Graduation Projects
Research Area
Research Area Reports
Search by Research Area
Universities Thesis
ACADEMIC Links
ACADEMIC RESEARCH
Zagazig University Authors
Africa Research Statistics
Google Scholar
Research Gate
Researcher ID
CrossRef
Potential therapeutic efficacy of pachymic acid in chronic kidney disease induced in rats: role of Wnt/β-catenin/renin–angiotensin axis
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Mohammed Abdul Rahman Ghoneim Shahin
Staff Zu Site
Abstract In Staff Site
Journal:
Journal of Pharmacy and Pharmacology Oxford University Press
Volume:
Keywords :
Potential therapeutic efficacy , pachymic acid , chronic
Abstract:
Objectives Chronic kidney disease (CKD) is a major public health problem associated with high mortality. The therapeutic effects of pachymic in CKD management and its underlying mechanisms have not been studied. Therefore, we aimed to investigate the possible inhibitory effect of PA on renal Wnt/β-catenin signalling in CKD. Methods CKD was induced in rats by doxorubicin (DOX; 3.5 mg/kg i.p., twice weekly for 3 weeks). Rats were treated orally with PA (10 mg/kg/day), LOS (10 mg/kg/day) or their combination (PA + LOS) for 4 weeks starting after the last dose of DOX. Key findings DOX-induced renal injury was characterized by high serum cystatin-C, and urine albumin/creatinine ratio, renal content of podocin and klotho were decreased. Tumour necrosis factor-α, interleukin-6, interleukin-1β, Wnt1, active β-catenin/total β-catenin ratio and fibronectin along with mRNA expression of RENIN, ACE and AT1 were increased in renal tissues. Treatment with either PA or LOS ameliorated all DOX-induced changes. The combined treatment was more effective in improving all changes than monotherapy. Conclusions These results suggest a new therapeutic benefit of PA in ameliorating CKD in rats through its up-regulatory effect on renal klotho thereby preventing Wnt/β-catenin reactivation and RAS gene expression. PA/LOS combination provided an additional inhibition of Wnt/β-catenin signalling and its downstream targets.
Author Related Publications
Mohammed Abdul Rahman Ghoneim Shahin, "A Comparative Study of the Ameliorative Effect of Doxorubicin with Vitamin E versus Liposomal Doxorubicin on the Left Ventricular Histological and Immunohisochemical Changes Induced by Doxorubicin in Adult Male Albino Rats", Lippincott Williams and Wilkins Ltd, 2019
More
Mohammed Abdul Rahman Ghoneim Shahin, "Pachymic acid attenuated doxorubicin-induced heart failure by suppressing miR-24 and preserving cardiac junctophilin-2 in rats.", MDPI, 2021
More
Mohammed Abdul Rahman Ghoneim Shahin, "Activation of Pak1/Akt/eNOS signaling following sphingosine-1-phosphate release as part of a mechanism protecting cardiomyocytes against ischemic cell injury", USA, 2011
More
Mohammed Abdul Rahman Ghoneim Shahin, "Therapeutic efficacy of bone marrow derived mesenchymal stromal cells versus losartan on adriamycin-induced renal cortical injury in adult albino rats.", Elsevier, 2016
More
Mohammed Abdul Rahman Ghoneim Shahin, "Plasma Membrane Calcium Pump (PMCA4)-Neuronal Nitric-oxide Synthase Complex Regulates Cardiac Contractility through Modulation of a Compartmentalized Cyclic Nucleotide Microdomain", Elsevier, 2011
More
Department Related Publications
Rawya Sarhan Amien Sarhan, "Physiological and Biochemical Changes in the Thawed Frozen Friesian Bull Semen", لايوجد, 1900
More
Soso Ibrahiem Ali Hasanien, "Dietary iron overload effect As Manipulated by fatty acids intake and their influence on testicular function", لايوجد, 1900
More
Mervat Alsayed Ibrahiem Elsayed Askar, "Hepatoprotective study of certain natural products on carbon tetrachloride induced hepatotoxicity in rats", لايوجد, 1900
More
Mervat Alsayed Ibrahiem Elsayed Askar, "Association of inflammatory, endothelial dysfunction markers and cardiovascular risk factors in ovariectomized STZ-diabetic rats", لايوجد, 1900
More
Mervat Alsayed Ibrahiem Elsayed Askar, "Hyperhomocysteinaemia and cardiovascular risk in female ovariectomized rats: Role of folic acid and hormone replacement therapy", لايوجد, 1900
More
جامعة المنصورة
جامعة الاسكندرية
جامعة القاهرة
جامعة سوهاج
جامعة الفيوم
جامعة بنها
جامعة دمياط
جامعة بورسعيد
جامعة حلوان
جامعة السويس
شراقوة
جامعة المنيا
جامعة دمنهور
جامعة المنوفية
جامعة أسوان
جامعة جنوب الوادى
جامعة قناة السويس
جامعة عين شمس
جامعة أسيوط
جامعة كفر الشيخ
جامعة السادات
جامعة طنطا
جامعة بنى سويف