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Impact of Melatonin on Full-Term Fetal Brain Development and Transforming Growth Factor-β Level in a Rat Model of Preeclampsia
Faculty
Medicine
Year:
2021
Type of Publication:
ZU Hosted
Pages:
Authors:
Nanis Fouad Salem Mohammed alMaliki
Staff Zu Site
Abstract In Staff Site
Journal:
Reproductive Sciences springer
Volume:
Keywords :
Impact , Melatonin , Full-Term Fetal Brain Development and
Abstract:
Preeclampsia (PE) is a leading cause of stroke and cognitive impairment in the offspring. Melatonin is involved in the outcome of normal pregnancy. Its receptors are widespread in the embryo. This study aimed to investigate the fetal neuroprotective effect of melatonin in experimentally induced PE. After induction of pregnancy in 18 female rats, they were divided into three equal groups. PE was induced in groups II and III by injection of deoxycorticosterone acetate and drinking isotonic saline. Melatonin was supplied to group III orally (10 mg/kg body weight) throughout pregnancy. Pregnancy was terminated on day 20, and macroanatomical investigation of three fetuses from each pregnant rat and their placentae was performed. Placental and brain homogenates were analyzed for malondialdehyde (MDA), placental growth factor (PLGF), tumor necrosis factor-α (TNF-α), and brain transforming growth factor-β (TGF-β). Histopathological analysis of fetal brain sections was performed. Melatonin improved placental, fetal, and brain weight; significantly reduced fetal death rate; significantly increased PLGF, placental and brain superoxide dismutase, and brain TGF-β; and significantly decreased placental TNF-α and brain MDA. Brain micromorphological study found normal glial cells and neuropil in the melatonin-treated group and a loss of neuronal cell outlines with an accumulation of cellular debris in the untreated group. In conclusion, melatonin approximately showed a neuroprotective activity by managing PE-induced oxidative stress in the placenta and fetal cerebral cortex of rats
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Department Related Publications
Ismail Alsayed Ismail, "A study on the effect of estrogen on cardiovascular responsiveness to adrenocoptors stimulators in experimental animals", لايوجد, 1900
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Shereen Alarabi Bedeer, "Modulations of serum hepcidin, IL6 and iron status by different exercise regimens in ovarectomized rats", International Journal of Advanced Research, 2015
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Azza Abdelrahman Youssef Megahed, "A STUDY ON EFFECT OF OMENTIN IN GLUCOSE AND LIPID METABOLISM IN NORMAL AND DIABETIC RATS", Lupus (2016) 0, 1–9, 2016
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