Thermoplastic nylon has numerous advantages, which was notable aesthetic, non-toxic properties, increased flexibility, but it has many problems like increased water permeable, liability to candida adhesion, difficult manipulation, and increasing surface roughness. Aim of the study To evaluate surface roughness and Candida albicans adhesion of polyamide resin denture base coated with various concentrations of MPC polymer, 2-methacryloyloxyethyl phosphorylcholine. Materials and Methods A total of eighty polyamide disks were prepared and divided into four groups (n = 20/group). Surfaces of specimens in three groups were treated with MPC in various concentrations (0.25mol/L; 0.50mol/L and 0.75mol/L), whereas uncoated specimens were used as control. Surface roughness (SR) was evaluated using a profilometer. Incubation of the specimens with C. albicans was done overnight, and the count of adhered cells was estimated. Statistically, the following tests were done: analysis of variance, Pearson correlation coefficient test, post hoc Tukey test. Results Upon PMPC coating, surface roughness values were decreased, with a significant difference between the groups. There was significant decrease in C. albicans count with the increase in the MPC polymer concentration. For the modified groups, 0.50mol/L and 0.75mol/L, showed no significant difference for candida adhesion while significantly different for surface roughness. These results showed that polymerization of MPC by graft method on polyamide denture base material decreases the attachment of C. albicans, consequently, it is recommended as a coating for elimination of denture stomatitis. Conclusions Modification of polyamide prosthesis with 0.75mol/L MPC is suitable to diminish C. albicans adhesion on the denture base and a decreasing effect on the surface roughness values.