Sixty orthodontic patients with non-carious molars scheduled for banding were randomly divided into three groups. Grouping was based on (3% MPC, 3% nano-Titanium, and 3%+3% of both by weight) added to the luting glass-ionomer cement (GIC) Medicem, which was used for cementation of prefabricated micro-etched orthodontic bands. Demineralization was recorded by using DiagnoDent pen (KaVo, Biberach, Germany) device. Statistical evaluation was performed with one way ANOA test. Results Bands cemented with conventional GIC showed the highest bacterial scores in comparison to those cemented with MPC polymer and nano-titanium modified GICs. There was significant difference between teeth banded with 3% MPC, 3% nano-titanium, and 3% MPC + 3% nano-titanium modified GICs. Conclusions MPC-containing dental materials may be promising to reduce the bacterial adhesion and biofilm formation at orthodontic appliances and the tooth-restoration margins. It could be applicable to a wide range of dental bonding agents, cements, sealants and composites. Additional studies are required for evaluating the physical properties of this modified GIC, and long term evaluation to their valuable effects. Modification of the banding GIC with MPC polymer and nano-titanium revealed a positive effect on reducing white spots around orthodontic bands.